ArticleJournal of the American Heart Association2015
Brain Arterial Diameters as a Risk Factor for Vascular Events.
Article in Journal of the American Heart Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Chromosome 10q24.32 Variants Associate With Brain Arterial Diameters in Diverse Populations: A Genome-Wide Association Study.Journal of the American Heart Association · 2023Pooled it
- Accurate and fully automated diameter measurements of Circle of Willis arteries on MRA imaging.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Article
- Cerebrovascular morphology: Insights into normal variations, aging effects and disease implications.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Review
- Design and Optimization of a Tapered Magnetic Soft Continuum Robot for Enhanced Navigation in Cerebral Vasculature.Micromachines · 2025Article
- Assessing changes on large cerebral arteries in CADASIL: Preliminary insights from a case-control analysis.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2025Observational
- Automated Cerebrovascular Segmentation and Visualization of Intracranial Time-of-Flight Magnetic Resonance Angiography Based on Deep Learning.Journal of imaging informatics in medicine · 2025Article
- Association of brain arterial diameters with demographic and anatomical factors in a multi-national pooled analysis of cohort studies.The neuroradiology journal · 2024Article
- Brain artery diameters and risk of dementia and stroke.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Article
- Association of Brain Arterial Elongation With Risk of Stroke and Death in Stroke-Free Individuals: Results From NOMAS.Arteriosclerosis, thrombosis, and vascular biology · 2023Article
- Chromosome 10q24.32 Variants Associate with Brain Arterial Diameters in Diverse Populations: A Genome-Wide Association Study.medRxiv : the preprint server for health sciences · 2023Article
- End to end stroke triage using cerebrovascular morphology and machine learning.Frontiers in neurology · 2023Article
- Chitinase-3 like-protein-1, matrix metalloproteinase -9 and positive intracranial arterial remodelling.Frontiers in aging neuroscience · 2023Article
- Dolichoectasia: a brain arterial disease with an elusive treatment.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Anatomical effects on the relationship between brain arterial diameter and length: The Northern Manhattan Study.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2022Article
- An evaluation of performance measures for arterial brain vessel segmentation.BMC medical imaging · 2021Article
- Relationship between 7T MR-angiography features of vascular injury and cognitive decline in young brain tumor patients treated with radiation therapy.Journal of neuro-oncology · 2021Article
- Pilot Study: Quantitative Photoacoustic Evaluation of Peripheral Vascular Dynamics Induced by Carfilzomib In Vivo.Sensors (Basel, Switzerland) · 2021Article
- Automatic segmentation, feature extraction and comparison of healthy and stroke cerebral vasculature.NeuroImage. Clinical · 2021Article
- Stroke Disparities: From Observations to Actions: Inaugural Edward J. Kenton Lecture 2020.Stroke · 2020Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundArterial luminal diameters are routinely used to assess for vascular disease. Although small diameters are typically considered pathological, arterial dilatation has also been associated with disease. We hypothesize that extreme arterial diameters are biomarkers of the risk of vascular events. METHODS AND
resultsParticipants in the Northern Manhattan Study who had a time-of-flight magnetic resonance angiography were included in this analysis (N=1034). A global arterial Z-score, called the brain arterial remodeling (BAR) score, was obtained by averaging the measured diameters within each individual. Individuals with a BAR score <-2 SDs were considered to have the smallest diameters, individuals with a BAR score >-2 and <2 SDs had average diameters, and individuals with a BAR score >2 SDs had the largest diameters. All vascular events were recorded prospectively after the brain magnetic resonance imaging. Spline curves and incidence rates were used to test our hypothesis. The association of the BAR score with death (P=0.001), vascular death (P=0.02), any vascular event (P=0.05), and myocardial infarction (P=0.10) was U-shaped except for ischemic stroke (P=0.74). Consequently, incidence rates for death, vascular death, myocardial infarction, and any vascular event were higher in individuals with the largest diameters, whereas individuals with the smallest diameters had a higher incidence of death, vascular death, any vascular event, and ischemic stroke compared with individuals with average diameters.
conclusionsThe risk of death, vascular death, and any vascular event increased at both extremes of brain arterial diameters. The pathophysiology linking brain arterial remodeling to systemic vascular events needs further research.
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