ArticleScientific reports2015
Streptococcus mutans copes with heat stress by multiple transcriptional regulons modulating virulence and energy metabolism.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 40 citations in OpenAlex.
- Molecular Regulation of Virulence and Dental Biofilm Formation in Streptococcus mutans: Unravelling the Crosstalk Between the VicRK and LiaSR Two-Component Systems.Molecular oral microbiology · 2026Review
- Coral-associated microbiome dynamics under thermal and pollution stress.Conservation biology : the journal of the Society for Conservation Biology · 2026Article
- Normoxic stress enhance the secretion of adhesion-promoting membrane vesicles byJournal of oral microbiology · 2026Article
- Metagenomic analysis reveals microbial drivers of heat resistance in dairy cattle.Animal microbiome · 2025Article
- The antibiofilm effect and mechanism of silver nanowire-modified glass ionomer cement against multi-species oral biofilm.BMC oral health · 2025Article
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- Fluoride export is required for competitive fitness of pathogenic microorganisms in dental biofilm models.bioRxiv : the preprint server for biology · 2024Article
- Antibacterial Evaluation of Zirconia Coated with Plasma-Based Graphene Oxide with Photothermal Properties.International journal of molecular sciences · 2023Article
- Growth with Commensal Streptococci AltersJournal of dental research · 2023Article
- Genome-Wide Identification of Novel sRNAs in Streptococcus mutans.Journal of bacteriology · 2022Article
- Transcriptomic Stress Response inMicroorganisms · 2022Article
- Influence of Fluoride-ResistantFrontiers in cellular and infection microbiology · 2022Article
- Robust Heat Shock Response inFrontiers in microbiology · 2021Article
- Understanding the Matrix: The Role of Extracellular DNA in Oral Biofilms.Frontiers in oral health · 2021Review
- Peptides encoded in theMicrobiology (Reading, England) · 2020Article
- Article
- Review: modulation of the oral microbiome by the host to promote ecological balance.Odontology · 2019Review
- Effects of Norspermidine on Dual-Species Biofilms Composed ofBioMed research international · 2019Article
- Susceptibility patterns and the role of extracellular DNA in Staphylococcus epidermidis biofilm resistance to physico-chemical stress exposure.BMC microbiology · 2018Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dental caries is closely associated with the virulence of Streptococcus mutans. The virulence expression of S. mutans is linked to its stress adaptation to the changes in the oral environment. In this work we used whole-genome microarrays to profile the dynamic transcriptomic responses of S. mutans during physiological heat stress. In addition, we evaluated the phenotypic changes, including, eDNA release, initial biofilm formation, extracellular polysaccharides generation, acid production/acid tolerance, and ATP turnover of S. mutans during heat stress. There were distinct patterns observed in the way that S. mutans responded to heat stress that included 66 transcription factors for the expression of functional genes being differentially expressed. Especially, response regulators of two component systems (TCSs), the repressors of heat shock proteins and regulators involved in sugar transporting and metabolism co-ordinated to enhance the cell's survival and energy generation against heat stress in S. mutans.
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