ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2015
How next-generation sequencing and multiscale data analysis will transform infectious disease management.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Rapid, reference-free identification of bacterial pathogen transmission using optimized splitMicrobial genomics · 2025Article
- Next Generation Sequencing in orthopaedic infections - Where is the road headed?Journal of clinical orthopaedics and trauma · 2024Article
- Case report: A toxoplasmic encephalitis in an immunocompromised child detected through metagenomic next-generation sequencing.Frontiers in public health · 2023Article
- Multi-site implementation of whole genome sequencing for hospital infection control: A prospective genomic epidemiological analysis.The Lancet regional health. Western Pacific · 2022Article
- Healthcare Associated Infections: An Interoperable Infrastructure for Multidrug Resistant Organism Surveillance.International journal of environmental research and public health · 2020Article
- Metagenomics in diagnosis and improved targeted treatment of UTI.World journal of urology · 2020Review
- Automated data mining of the electronic health record for investigation of healthcare-associated outbreaks.Infection control and hospital epidemiology · 2019Article
- Big Data Analytics, Infectious Diseases and Associated Ethical Impacts.Philosophy & technology · 2019Article
- Next-Generation Sequencing Coupled WithFrontiers in veterinary science · 2019Review
- Genomic Surveillance Reveals Diversity of Multidrug-Resistant Organism Colonization and Infection: A Prospective Cohort Study in Liver Transplant Recipients.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- Mapping the Evolutionary Potential of RNA Viruses.Cell host & microbe · 2018Review
- Dynamics of monocytic HLA-DR expression differs between bacterial etiologies during the course of bloodstream infection.PloS one · 2018Article
- Estimating Local Costs Associated With Clostridium difficile Infection Using Machine Learning and Electronic Medical Records.Infection control and hospital epidemiology · 2017Article
- Challenges in fecal donor selection and screening for fecal microbiota transplantation: A review.Gut microbes · 2017Review
- Community-Acquired CavitaryCase reports in infectious diseases · 2017Article
- Article
- Antimicrobial Stewardship: How the Microbiology Laboratory Can Right the Ship.Clinical microbiology reviews · 2017Review
- Illuminating uveitis: metagenomic deep sequencing identifies common and rare pathogens.Genome medicine · 2016Article
- Advanced Molecular Detection of Malarone Resistance.Antimicrobial agents and chemotherapy · 2016Article
Corrections and comments
- Commented on byReply to Lesho.2016
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent reviews have examined the extent to which routine next-generation sequencing (NGS) on clinical specimens will improve the capabilities of clinical microbiology laboratories in the short term, but do not explore integrating NGS with clinical data from electronic medical records (EMRs), immune profiling data, and other rich datasets to create multiscale predictive models. This review introduces a range of "omics" and patient data sources relevant to managing infections and proposes 3 potentially disruptive applications for these data in the clinical workflow. The combined threats of healthcare-associated infections and multidrug-resistant organisms may be addressed by multiscale analysis of NGS and EMR data that is ideally updated and refined over time within each healthcare organization. Such data and analysis should form the cornerstone of future learning health systems for infectious disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.