ArticleBMC oral health2015
S100, bcl2 and myeloperoxid protein expirations during periodontal inflammation.
Article in BMC oral health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- Unveiling the Molecular Landscape of MPO in Kikuchi's Disease: Protein Expression, mRNA Levels, and Genetic Polymorphisms.International journal of laboratory hematology · 2025Article
- The investigation of apoptosis-related genes in periodontitis.BMC research notes · 2025Article
- Senescent cells exacerbate chronic inflammation and contribute to periodontal disease progression in old mice.Journal of periodontology · 2021Article
- Peculiarities of vascular endothelial growth factor of oral cavity in atopic condition VEGF of oral cavity in atopic condition.Interventional medicine & applied science · 2021Article
- PCR array analysis identified hyperproliferation but not autophagy or apoptosis in fibrous epulis.Journal of clinical laboratory analysis · 2021Article
- Key Elements of Gingival Epithelial Homeostasis upon Bacterial Interaction.Journal of dental research · 2021Review
- Body temperature-dependent microRNA expression analysis in rats: rno-miR-374-5p regulates apoptosis in skeletal muscle cells via Mex3B under hypothermia.Scientific reports · 2020Article
- The RAS-PI3K-AKT-NF-κB pathway transcriptionally regulates the expression of BCL2 family and IAP family genes and inhibits apoptosis in fibrous epulis.Journal of clinical laboratory analysis · 2020Article
- Opportunistic PathogenFrontiers in cellular and infection microbiology · 2017Article
- Characteristics of cellular composition of periodontal pockets.Interventional medicine & applied science · 2016Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeriodontal inflammation is characterized by injuries in collagen, epithelial, bone tissues. The hypotheses to be tested were relationship between the s100, bcl2 and myeloperoxidase in gingival tissues (MPO does affect the level of s100, bcl2). The object of this study was to investigate of s100 expression, bcl2 expression and myeloperoxidase expression in periodontal inflammation.
methods27 patients (giant-cell epulis) and 30 patients (acute and chronic inflammations) were included in the study for s100 expression, bcl2 expression and myeloperoxidase expression by immunohistochemistry and hematoxylin--eosin.
resultsGiant-cells in epulis positivity for myeloperoxidase has been observed in 100% However, only 75.31% of giant-cells were positive for bcl2 expression. Acute 98.2%, and chronic 89.28% inflammation was a significant positive for myeloperoxidase. The immunohistochemical findings of s100, bcl 2 and myeloperoxidase in epithelial layers have showed the result of 100%, 82,2%, 100% positive cells in acute and 100%, 78.25%, 100% in chronic process of inflammation respectively.
conclusionThe results indicate that the pathogenesis of periodontal inflammation might involve inhibition of cell death, through the overexpression of bcl-2, due to identifying factors myeloperoxidase (result in the DNA damage by the product of catalysis). The highest levels of s100 activity have been found at sites with chronic inflammation.
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