ArticleBMC genomics2015
Putative type 1 thymidylate synthase and dihydrofolate reductase as signature genes of a novel Bastille-like group of phages in the subfamily Spounavirinae.
Article in BMC genomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
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- Exploration into the origins and mobilization of di-hydrofolate reductase genes and the emergence of clinical resistance to trimethoprim.Microbial genomics · 2020Article
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- Complete Nucleotide Sequence Analysis of a NovelViruses · 2018Article
- VICTOR: genome-based phylogeny and classification of prokaryotic viruses.Bioinformatics (Oxford, England) · 2017Article
- Article
- How to Name and Classify Your Phage: An Informal Guide.Viruses · 2017Article
- Phages rarely encode antibiotic resistance genes: a cautionary tale for virome analyses.The ISME journal · 2017Article
- Three novel bacteriophages isolated from the East African Rift Valley soda lakes.Virology journal · 2016Article
- Complete Genome Sequence of Bacteriophage Deep-Blue Infecting Emetic Bacillus cereus.Genome announcements · 2016Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSpounavirinae viruses have received an increasing interest as tools for the control of harmful bacteria due to their relatively broad host range and strictly virulent phenotype.
resultsIn this study, we collected and analyzed the complete genome sequences of 61 published phages, either ICTV-classified or candidate members of the Spounavirinae subfamily of the Myoviridae. A set of comparative analyses identified a distinct, recently proposed Bastille-like phage group within the Spounavirinae. More importantly, type 1 thymidylate synthase (TS1) and dihydrofolate reductase (DHFR) genes were shown to be unique for the members of the proposed Bastille-like phage group, and are suitable as molecular markers. We also show that the members of this group encode beta-lactamase and/or sporulation-related SpoIIIE homologs, possibly questioning their suitability as biocontrol agents.
conclusionsWe confirm the creation of a new genus--the "Bastille-like group"--in Spounavirinae, and propose that the presence of TS1- and DHFR-encoding genes could serve as signatures for the new Bastille-like group. In addition, the presence of metallo-beta-lactamase and/or SpoIIIE homologs in all members of Bastille-like group phages makes questionable their suitability for use in biocontrol.
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