ArticleCritical care (London, England)2015
Hyperdynamic left ventricular ejection fraction in the intensive care unit.
Article in Critical care (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Left ventricular systolic function evaluated by strain echocardiography and relationship with mortality in patients with severe sepsis or septic shock: a systematic review and meta-analysis.Critical care (London, England) · 2018Pooled it
- HIMAP POCUS protocol for early evaluation of undifferentiated shocked patients at the emergency department: A prospective study of diagnostic accuracy and time efficiency.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2026Article
- A structured 5-question approach for echocardiographic evaluation of undifferentiated shock.Echo research and practice · 2026Review
- Cardiovascular Performance in Neonates with Hypoxic-Ischemic Encephalopathy Under Therapeutic Hypothermia: Evaluation by Conventional and Advanced Echocardiographic Techniques.Pediatric cardiology · 2026Observational
- Characterizing Heart Failure Across the Spectrum of the Preserved Ejection Fraction: Does Heart Failure With Supranormal Ejection Fraction Exist? Data From the Swedish Heart Failure Registry.Journal of the American Heart Association · 2025Article
- Septic Cardiomyopathy: Difficult Definition, Challenging Diagnosis, Unclear Treatment.Journal of clinical medicine · 2025Review
- Supranormal Left Ventricular Ejection Fraction, Concentric Remodeling, and Long-Term Survival.JACC. Asia · 2024Article
- Influence of age and sex on physical, cardiac electrical and functional alterations in progressive hyperoxia treatment: A time course study in a murine model.Experimental gerontology · 2024Article
- Prevalence and prognosis of hyperdynamic left ventricular systolic function in septic patients: a systematic review and meta-analysis.Annals of intensive care · 2024Article
- Assessment of Pulmonary Circulation of Critically Ill Patients Based on Critical Care Ultrasound.Journal of clinical medicine · 2024Review
- Heart-lung crosstalk in acute respiratory distress syndrome.Frontiers in physiology · 2024Review
- Shock indices are associated with in-hospital mortality among patients with septic shock and normal left ventricular ejection fraction.PloS one · 2024Article
- Decoding molecular signature on heart of septic mice with distinct left ventricular ejection fraction.iScience · 2023Article
- Echocardiographic profiles and hemodynamic response after vasopressin initiation in septic shock: A cross-sectional study.Journal of critical care · 2023Article
- Early Serial Echocardiographic and Ultrasonographic Findings in Critically Ill Patients With COVID-19.CHEST critical care · 2023Article
- Cardiovascular Subphenotypes in ARDS: Diagnostic and Therapeutic Implications and Overlap with Other ARDS Subphenotypes.Journal of clinical medicine · 2023Review
- Sepsis-Induced myocardial dysfunction: heterogeneity of functional effects and clinical significance.Frontiers in cardiovascular medicine · 2023Review
- Review
- Sex-specific differences in cardiac function, inflammation and injury during early polymicrobial sepsis.Intensive care medicine experimental · 2022Article
- Hyperdynamic left ventricular ejection fraction is associated with higher mortality in COVID-19 patients.American heart journal plus : cardiology research and practice · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
introductionLimited information exists on the etiology, prevalence, and significance of hyperdynamic left ventricular ejection fraction (HDLVEF) in the intensive care unit (ICU). Our aim in the present study was to compare characteristics and outcomes of patients with HDLVEF with those of patients with normal left ventricular ejection fraction in the ICU using a large, public, deidentified critical care database.
methodsWe conducted a longitudinal, single-center, retrospective cohort study of adult patients who underwent echocardiography during a medical or surgical ICU admission at the Beth Israel Deaconess Medical Center using the Multiparameter Intelligent Monitoring in Intensive Care II database. The final cohort had 2867 patients, of whom 324 had HDLVEF, defined as an ejection fraction >70%. Patients with an ejection fraction <55% were excluded.
resultsCompared with critically ill patients with normal left ventricular ejection fraction, the finding of HDLVEF in critically ill patients was associated with female sex, increased age, and the diagnoses of hypertension and cancer. Patients with HDLVEF had increased 28-day mortality compared with those with normal ejection fraction in multivariate logistic regression analysis adjusted for age, sex, Sequential Organ Failure Assessment score, Elixhauser score for comorbidities, vasopressor use, and mechanical ventilation use (odds ratio 1.38, 95% confidence interval 1.039-1.842, p =0.02).
conclusionsThe presence of HDLVEF portended increased 28-day mortality, and may be helpful as a gravity marker for prognosis in patients admitted to the ICU. Further research is warranted to gain a better understanding of how these patients respond to common interventions in the ICU and to determine if pharmacologic modulation of HDLVEF improves outcomes.
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