ArticleInternational journal of geriatric psychiatry2016
Amyloid-associated depression and ApoE4 allele: longitudinal follow-up for the development of Alzheimer's disease.
Article in International journal of geriatric psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Association between apolipoprotein E gene polymorphism and mild cognitive impairment: a meta-analysis.Clinical interventions in aging · 2017Pooled it
- Differential effects of soluble and plaque amyloid on late-life depression: The moderating role of tau pathology.The journal of prevention of Alzheimer's disease · 2025Article
- Defining the contributions of tau pathology in the amygdala to increasing depressive symptoms in aging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Differential neuropsychiatric associations of plasma biomarkers in older adults with major depression and subjective cognitive decline.Translational psychiatry · 2024Article
- Causal feature selection using a knowledge graph combining structured knowledge from the biomedical literature and ontologies: A use case studying depression as a risk factor for Alzheimer's disease.Journal of biomedical informatics · 2023Article
- Crosstalk between Depression and Breast Cancer via Hepatic Epoxide Metabolism: A Central Comorbidity Mechanism.Molecules (Basel, Switzerland) · 2022Review
- Article
- Default mode network dissociation linking cerebral beta amyloid retention and depression in cognitively normal older adults.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Antidepressants in Alzheimer's Disease: A Focus on the Role of Mirtazapine.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Mid to late-life scores of depression in the cognitively healthy are associated with cognitive status and Alzheimer's disease pathology at death.International journal of geriatric psychiatry · 2021Article
- Associations of AT(N) biomarkers with neuropsychiatric symptoms in preclinical Alzheimer's disease and cognitively unimpaired individuals.Translational neurodegeneration · 2021Review
- Association of Midlife Depressive Symptoms with Regional Amyloid-β and Tau in the Framingham Heart Study.Journal of Alzheimer's disease : JAD · 2021Article
- High depression and anxiety in people with Alzheimer's disease living in retirement homes during the covid-19 crisis.Psychiatry research · 2020Article
- Pseudodementia, pseudo-pseudodementia, and pseudodepression.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- Diagnosing and Treating Depression in Patients with Alzheimer's Disease.Neurology and therapy · 2019Review
- Beta-amyloid deposition in patients with major depressive disorder with differing levels of treatment resistance: a pilot study.EJNMMI research · 2017Article
- Clinicopathological correlates of depression in early Alzheimer's disease in the NACC.International journal of geriatric psychiatry · 2016Article
- Polymorphisms of apolipoprotein E and aneurysmal subarachnoid haemorrhage: A meta-analysis.Meta gene · 2016Review
- Mood disorders in the elderly: prevalence, functional impact, and management challenges.Neuropsychiatric disease and treatment · 2016Review
- Automated identification of older adults at risk for cognitive decline.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundAmyloid-associated depression is associated with cognitive impairment cross sectionally. This follow-up study was to determine the relationship between amyloid-associated depression and the development of Alzheimer's disease (AD).
methodsTwo hundred and twenty three subjects who did not have dementia at baseline were given a repeat cognitive evaluation for incident AD. Depression was defined by having a Center for Epidemiological Studies Depression (CES-D) score ≥ 16, and non-amyloid vs. amyloid-associated depression by having a low vs. high plasma amyloid-β peptide 40 (Aβ40)/Aβ42 ratio. Apolipoprotein E (ApoE) genotype was determined, and antidepressant usage was documented.
resultsFifteen subjects developed AD (7%) after an average follow-up time of 6.2 years. While none of those with non-amyloid depression developed AD, 9% of those with amyloid-associated depression developed AD. Further, among those with amyloid-associated depression, ApoE4 carriers tended to have a higher risk of AD than ApoE4 non-carriers (40% vs. 4%, p = 0.06). In contrast, 8% of those who did not have depression at baseline developed AD, but ApoE4 carriers and non-carriers did not show a difference in the AD risk. After adjusting for age, the interaction between ApoE4 and amyloid-associated depression (β = +0.113, SE = 0.047, P = 0.02) and the interaction between ApoE4 and antidepressant use (β = +0.174, SE = 0.064, P = 0.007) were associated with the AD risk.
conclusionsAmyloid-associated depression may be prodromal depression of AD especially in the presence of ApoE4. Future studies with a larger cohort and a longer follow-up are warranted to further confirm this conclusion.
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