ArticleClinical oral investigations2016
Regenerative endodontic procedure of an infected immature permanent human tooth: an immunohistological study.
Article in Clinical oral investigations, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Tissue Characteristics in Endodontic Regeneration: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Human amniotic membrane as an extracellular matrix scaffold in regenerative endodontics: A cell homing perspective.Journal of conservative dentistry and endodontics · 2026Review
- Optimizing methods for regenerative endodontics.Regenerative medicine · 2025Review
- Regenerative Therapy for the Permanent Immature Teeth: A Long Term Study. An Original Research.Journal of pharmacy & bioallied sciences · 2023Article
- Loss of Stat3 in OsterixCell & bioscience · 2023Article
- Effect of Intracoronal Sealing Biomaterials on the Histological Outcome of Endodontic Revitalisation in Immature Sheep Teeth-A Pilot Study.Journal of functional biomaterials · 2023Article
- Neural Regeneration in Regenerative Endodontic Treatment: An Overview and Current Trends.International journal of molecular sciences · 2022Review
- Outcomes reporting in systematic reviews on revitalization: A scoping review for the development of a core outcome set.International endodontic journal · 2022Article
- Human Amnion Epithelial Cells: A Potential Cell Source for Pulp Regeneration?International journal of molecular sciences · 2022Article
- Regenerative Endodontics Success Factors and their Overall Effectiveness: An Umbrella Review.Iranian endodontic journal · 2022Review
- Evaluation of the regenerative potential of dentin conditioning and naturally derived scaffold for necrotic immature permanent teeth in a dog model.International journal of experimental pathology · 2020Article
- Distinctive role of ACVR1 in dentin formation: requirement for dentin thickness in molars and prevention of osteodentin formation in incisors of mice.Journal of molecular histology · 2019Article
- Evaluation of mesenchymal stem cell modulation of trigeminal neuronal responses to cold.Neuroscience · 2017Article
- Impact of CD34-dependent Micro Vessel Density on Periapical Odontogenic Cysts.Cancer diagnosis & prognosisArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAn immunohistological study of an infected immature permanent human tooth after a regenerative endodontic procedure (REP) was conducted in order to determine the histologic outcome of this procedure. Besides observed signs of angiogenesis and neurogenesis, repair and/or regeneration of the pulp-dentin complex was also investigated. MATERIALS AND
methodsA REP was performed on tooth 45 of a 10-year-old girl. Eleven months post-treatment, the tooth had to be removed for orthodontic reasons. The following investigations were performed: immunohistology and radiographic quantification of root development. After hematoxylin-eosin (HE) staining, the following immunomarkers were selected: neurofilament (NF), pan cytokeratin (PK), osteocalcin (OC), and CD34.
resultsThe REP resulted in clinical and radiographic healing of the periradicular lesion and quantifiable root development. The HE staining matches with the medical imaging post-REP: underneath the mineral trioxide aggregate a calcified bridge with cell inclusions, connective pulp-like tissue (PLT) with blood vessels, osteodentin against the root canal walls, on the root surface cementum (Ce), and periodontal ligament (PDL). The PDL was PK(+). The blood vessels in the PLT and PDL were CD34(+). The Ce, osteodentin, and stromal cells in the PLT were OC(+). The neurovascular bundles in the PLT were NF(+).
conclusionsImmunohistologically, REP of this infected immature permanent tooth resulted in an intracanalar connective tissue with a regulated physiology, but not pulp tissue. CLINICAL RELEVANCE: REP of an immature permanent infected tooth may heal the periapical infection and may result in a combination of regeneration and repair of the pulp-dentin complex.
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