Evidence map›Paper›PMID 26250744›Full record

ArticleThe British journal of psychiatry : the journal of mental science2016

Cognitive and neurophysiological markers of ADHD persistence and remission.

Celeste H M Cheung, Fruhling Rijsdijk, Gráinne McLoughlin, Daniel Brandeis, Tobias Banaschewski, Philip Asherson, Jonna Kuntsi

Open access · bronzeAbstract read
In one paragraph

Article in The British journal of psychiatry : the journal of mental science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 3 pooled it
9.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 3 syntheses or guidelines pooled it, 144 citations in OpenAlex.

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  18. The Loudness Dependence of Auditory Evoked Potentials is associated with the Symptom Severity and Treatment in Boys with Attention Deficit Hyperactivity Disorder.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2022
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10 more citing papers are in PubMed but not listed here.

4 · The record

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5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Celeste H M CheungCeleste H. M. Cheung, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK and Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Fruhling Rijsdijk, PhD, Gráinne McLoughlin, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK; Daniel Brandeis, PhD, Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany, Department of Child and Adolescent Psychiatry, University of Zurich, Zurich, Switzerland, Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland, and Neuroscience Center Zurich, University of Zurich, Zurich, Switzerland; Tobias Banaschewski, MD, PhD, Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany; Philip Asherson, MRC Psych, PhD, Jonna Kuntsi, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK.
Fruhling RijsdijkCeleste H. M. Cheung, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK and Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Fruhling Rijsdijk, PhD, Gráinne McLoughlin, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK; Daniel Brandeis, PhD, Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany, Department of Child and Adolescent Psychiatry, University of Zurich, Zurich, Switzerland, Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland, and Neuroscience Center Zurich, University of Zurich, Zurich, Switzerland; Tobias Banaschewski, MD, PhD, Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany; Philip Asherson, MRC Psych, PhD, Jonna Kuntsi, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK.
Gráinne McLoughlinCeleste H. M. Cheung, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK and Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Fruhling Rijsdijk, PhD, Gráinne McLoughlin, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK; Daniel Brandeis, PhD, Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany, Department of Child and Adolescent Psychiatry, University of Zurich, Zurich, Switzerland, Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland, and Neuroscience Center Zurich, University of Zurich, Zurich, Switzerland; Tobias Banaschewski, MD, PhD, Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany; Philip Asherson, MRC Psych, PhD, Jonna Kuntsi, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK.
Daniel BrandeisCeleste H. M. Cheung, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK and Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Fruhling Rijsdijk, PhD, Gráinne McLoughlin, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK; Daniel Brandeis, PhD, Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany, Department of Child and Adolescent Psychiatry, University of Zurich, Zurich, Switzerland, Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland, and Neuroscience Center Zurich, University of Zurich, Zurich, Switzerland; Tobias Banaschewski, MD, PhD, Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany; Philip Asherson, MRC Psych, PhD, Jonna Kuntsi, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK.
Tobias BanaschewskiCeleste H. M. Cheung, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK and Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Fruhling Rijsdijk, PhD, Gráinne McLoughlin, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK; Daniel Brandeis, PhD, Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany, Department of Child and Adolescent Psychiatry, University of Zurich, Zurich, Switzerland, Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland, and Neuroscience Center Zurich, University of Zurich, Zurich, Switzerland; Tobias Banaschewski, MD, PhD, Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany; Philip Asherson, MRC Psych, PhD, Jonna Kuntsi, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK.
Philip AshersonCeleste H. M. Cheung, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK and Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Fruhling Rijsdijk, PhD, Gráinne McLoughlin, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK; Daniel Brandeis, PhD, Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany, Department of Child and Adolescent Psychiatry, University of Zurich, Zurich, Switzerland, Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland, and Neuroscience Center Zurich, University of Zurich, Zurich, Switzerland; Tobias Banaschewski, MD, PhD, Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany; Philip Asherson, MRC Psych, PhD, Jonna Kuntsi, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK.
Jonna KuntsiCeleste H. M. Cheung, MSc, King's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK and Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Fruhling Rijsdijk, PhD, Gráinne McLoughlin, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK; Daniel Brandeis, PhD, Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany, Department of Child and Adolescent Psychiatry, University of Zurich, Zurich, Switzerland, Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland, and Neuroscience Center Zurich, University of Zurich, Zurich, Switzerland; Tobias Banaschewski, MD, PhD, Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany; Philip Asherson, MRC Psych, PhD, Jonna Kuntsi, PhD, King's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK jonna.kuntsi@kcl.ac.uk.
Central Institute of Mental Health · DEHeidelberg University · DEKing's College London · GBUniversity Hospital Heidelberg · DE

Funding

International Multi-Center ADHD Genetics ProjectR01MH062873 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI FARAONE, STEPHEN V · 2002 to 2007
$7.2M
Medical Research Council G0300189Medical Research Council MR/N013182/1NIMH NIH HHS R01 MH062873
6 · The paper itself

Abstract

backgroundAttention-deficit hyperactivity disorder (ADHD) persists in around two-thirds of individuals in adolescence and early adulthood.

aimsTo examine the cognitive and neurophysiological processes underlying the persistence or remission of ADHD.

methodFollow-up data were obtained from 110 young people with childhood ADHD and 169 controls on cognitive, electroencephalogram frequency, event-related potential (ERP) and actigraph movement measures after 6 years.

resultsADHD persisters differed from remitters on preparation-vigilance measures (contingent negative variation, delta activity, reaction time variability and omission errors), IQ and actigraph count, but not on executive control measures of inhibition or working memory (nogo-P3 amplitudes, commission errors and digit span backwards).

conclusionsPreparation-vigilance measures were markers of remission, improving concurrently with ADHD symptoms, whereas executive control measures were not sensitive to ADHD persistence/remission. For IQ, the present and previous results combined suggest a role in moderating ADHD outcome. These findings fit with previously identified aetiological separation of the cognitive impairments in ADHD. The strongest candidates for the development of non-pharmacological interventions involving cognitive training and neurofeedback are the preparation-vigilance processes that were markers of ADHD remission.

Indexed as

Disease ProgressionActigraphyAdolescentArousalAttention Deficit Disorder with HyperactivityChildElectroencephalographyEvoked PotentialsExecutive FunctionFemaleFollow-Up StudiesHumansIntelligenceMaleRemission, SpontaneousSiblings

Identifiers

PMID26250744
PMCPMC4887724
OpenAlexW1828299506

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.