ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2015
Sox10ER(T2) CreER(T2) mice enable tracing of distinct neural crest cell populations.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Postnatal sustentacular cells as chromaffin progenitors and tumor cells of origin in VHL-related paragangliomas.NPJ precision oncology · 2025Article
- PDGFRα/β heterodimer activation negatively affects downstream ERK1/2 signaling and cellular proliferation.Nature communications · 2025Article
- Disruption of DNA methylation-mediated cranial neural crest proliferation and differentiation causes orofacial clefts in mice.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Reproducible strategy for excisional skin-wound-healing studies in mice.Nature protocols · 2024Review
- Resolving the lineage relationship between malignant cells and vascular cells in glioblastomas.Protein & cell · 2023Article
- Gene regulatory network from cranial neural crest cells to osteoblast differentiation and calvarial bone development.Cellular and molecular life sciences : CMLS · 2022Review
- Sox10-cre BAC transgenes reveal temporal restriction of mesenchymal cranial neural crest and identify glandular Sox10 expression.Developmental biology · 2021Article
- The heart of the neural crest: cardiac neural crest cells in development and regeneration.Development (Cambridge, England) · 2020Review
- Article
- Cre-driver lines used for genetic fate mapping of neural crest cells in the mouse: An overview.Genesis (New York, N.Y. : 2000) · 2018Review
- Pdgfra and Pdgfrb genetically interact during craniofacial development.Developmental dynamics : an official publication of the American Association of Anatomists · 2016Article
- Deficiency of 14-3-3ε and 14-3-3ζ by the Wnt1 promoter-driven Cre recombinase results in pigmentation defects.BMC research notes · 2016Article
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2 authors at 1 institution in 1 country.
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Abstract
backgroundNeural crest cells play an important role in craniofacial morphogenesis and many other developmental processes. The formation of neural crest cells (NCCs) in vivo is a highly dynamic process and remains to be fully understood.
resultsTo investigate the spatiotemporal patterning of NCCs in vivo, we have generated Sox10ER(T2) CreER(T2) (SECE) mice, a transgenic line driving inducible Cre expression in NCCs. Inducing Cre activity at different stages triggered reporter expression in distinct NCC populations in SECE; R26R mice. By optimizing the timing and dosage of tamoxifen administration, we controlled Cre expression specifically in cranial NCCs. Using this approach, we demonstrate an important role for PDGFRα in cranial NCCs mitosis within the mandibular processes. Further reducing Cre activity within the cranial NCCs of SECE; R26R embryos revealed that SECE labels preferentially progenitors of medial nasal process (MNP) rather than the lateral nasal process (LNP), before their formation from the frontonasal prominence (FNP).
conclusionsOur results indicate that NCCs are formed sequentially from rostral to caudal regions along the neural tube. These findings also suggest that NCCs within the FNP become specified regionally and genetically before they divide into MNP and LNP.
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