ArticleJournal of gastroenterology and hepatology2016
Patterns and prognostic value of lymph node dissection for resected perihilar cholangiocarcinoma.
Article in Journal of gastroenterology and hepatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Can the Limits of Liver Transplantation Be Expanded in Perihilar Cholangiocarcinoma?Journal of gastrointestinal cancer · 2022Pooled it
- Pooled it
- Predicting preoperative lymph node metastasis of hilar cholangiocarcinoma based on deep learning radiomics.The ultrasound journal · 2026Article
- Development and validation of a machine learning-based nomogram for survival prediction of patients with hilar cholangiocarcinoma after curative-intent resection.Scientific reports · 2025Article
- Prognostic impact of lymph node and surgical margin in patients with perihilar cholangiocarcinoma.European journal of medical research · 2025Article
- Prognostic Significance of Lymph Node Ratio in Intrahepatic and Extrahepatic Cholangiocarcinomas.Cancers · 2025Article
- Radiographic features predictive of recurrence and survival after surgical resection of perihilar cholangiocarcinoma.Heliyon · 2024Article
- Development and validation of a novel preoperative clinical model for predicting lymph node metastasis in perihilar cholangiocarcinoma.BMC cancer · 2024Article
- "Five steps four quadrants" modularizedWorld journal of gastrointestinal surgery · 2024Article
- Rational Extent of Regional Lymphadenectomy and the Prognostic Impact of the Number of Positive Lymph Nodes for Perihilar Cholangiocarcinoma.Annals of surgical oncology · 2023Article
- Survival analysis of extrahepatic cholangiocarcinoma based on surveillance, epidemiology, and end results database.Annals of hepato-biliary-pancreatic surgery · 2023Article
- Predictors of Distant Metastasis and Prognosis in Newly Diagnosed T1 Intrahepatic Cholangiocarcinoma.BioMed research international · 2023Review
- The influence ofHepatobiliary surgery and nutrition · 2022Article
- Evaluation of Four Lymph Node Classifications for the Prediction of Survival in Hilar Cholangiocarcinoma.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2022Article
- Prognostic nomogram for predicting cancer-specific survival in patients with resected hilar cholangiocarcinoma: a large cohort study.Journal of gastrointestinal oncology · 2022Article
- A novel nomogram for adult primary perihilar cholangiocarcinoma and considerations concerning lymph node dissection.Frontiers in surgery · 2022Article
- The value of lymphadenectomy in surgical resection of perihilar cholangiocarcinoma: a systematic review and meta-analysis.International journal of clinical oncology · 2021Review
- External validation study of the 8Journal of gastrointestinal oncology · 2021Article
- Evaluation and Recommendation of the 8th Edition of American Joint Committee on Cancer (AJCC) Staging System for Intrahepatic Cholangiocarcinoma (ICC) in 820 Patients from the Surveillance, Epidemiology, and End Results (SEER) Database.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021Article
- A Novel Nomogram Based on Log Odds of Metastatic Lymph Nodes to Predict Overall Survival in Patients With Perihilar Cholangiocarcinoma After Surgery.Frontiers in oncology · 2021Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
aimLymph node metastasis is a major prognostic factor for perihilar cholangiocarcinoma (PHC). However, prognostic significance of extent of node dissection, lymph node ratio (LNR), and number and location of positive nodes remain unclear. We aimed to evaluate whether node status, LNR, or number or location of positive nodes are independent factors for staging in PHC and to determine the minimum requirements for node examination.
methodsThe Surveillance, Epidemiology, and End Results database was used to identify 1116 resected PHCs from 1998 to 2008. The correlation between nodal status and survival was analyzed retrospectively.
resultsLymph node metastasis occurred in 43.4% patients and was an independent predictor for overall survival and cancer-specific survival. No survival benefit was observed for an increasing number of node retrieval in node-positive patients. However, in node-negative patients, ≥13 node dissection was of more survival benefit than 3 ≤ total lymph node count (TLNC) ≤ 12 and TLNC < 3 (5-year overall survival: 52.8% vs 39.7% vs 26.3%, P = 0.001; 5-year cancer-specific survival: 60.6% vs 46.3% vs 30.0%, P = 0.001). No difference in survival between patients with regional and distant node involvement was found. Survival for patients with greater than three positive nodes was significantly worse than that for those with three or less (relative ratio: 1.466, P = 0.001). And patients with LNR > 0.27 also had unfavorable prognosis (relative ratio: 1.376, P = 0.001).
conclusionsWe determined that to adequately assess nodal status of this life-threatening disease, 13 or more nodes retrieval should be considered. Number of positive nodes and LNR rather than location of metastatic nodes may be defined as parameters for staging of PHC.
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