ArticleCancer causes & control : CCC2015
Association of diabetes and cancer mortality in American Indians: the Strong Heart Study.
Article in Cancer causes & control : CCC, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Diabetes mellitus and colorectal carcinoma outcomes: a meta-analysis.International journal of colorectal disease · 2020Pooled it
- Diabetes mellitus and the risk of gastric cancer: a meta-analysis of cohort studies.Oncotarget · 2017Pooled it
- Trends and Disparities in Cancer-Related Mortality Among Adults With Diabetes in the United States: 1999-2019.Endocrinology, diabetes & metabolism · 2025Review
- Advancing environmental epidemiologic methods to confront the cancer burden.American journal of epidemiology · 2025Article
- Formative Assessment to Improve Cancer Screenings in American Indian Men: Native Patient Navigator and mHealth Texting.International journal of environmental research and public health · 2022Article
- Renal Cell Carcinoma Surgical Treatment Disparities in American Indian/Alaska Natives and Hispanic Americans in Arizona.International journal of environmental research and public health · 2022Article
- Cancer mortality in a population-based cohort of American Indians - The strong heart study.Cancer epidemiology · 2021Article
- The Relationship between Diabetes Mellitus and Gastric Cancer and the Potential Benefits of Metformin: An Extensive Review of the Literature.Biomolecules · 2021Review
- Article
- Diabetes Mellitus and Cause-Specific Mortality: A Population-Based Study.Diabetes & metabolism journal · 2019Article
- Hyperglycemia, Classified with Multiple Biomarkers Simultaneously in Men without Diabetes, and Risk of Fatal Prostate Cancer.Cancer prevention research (Philadelphia, Pa.) · 2019Article
- Food choices and distress in reservation-based American Indians and Alaska Natives with type 2 diabetes.Public health nutrition · 2018Article
- Serum microRNA profiling and bioinformatics analysis of patients with type 2 diabetes mellitus in a Chinese population.Molecular medicine reports · 2017Article
- Diabetes and mortality in patients with prostate cancer: a meta-analysis.SpringerPlus · 2016Review
- Milk: an epigenetic amplifier of FTO-mediated transcription? Implications for Western diseases.Journal of translational medicine · 2015Review
Corrections and comments
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Authors and funding
13 authors at 7 institutions in 2 countries.
Funding
Abstract
purposeThe metabolic abnormalities that accompany diabetes mellitus are associated with an increased risk of many cancers. These associations, however, have not been well studied in American Indian populations, which experience a high prevalence of diabetes. The Strong Heart Study is a population-based, prospective cohort study with extensive characterization of diabetes status.
methodsAmong a total cohort of 4,419 participants who were followed for up to 20 years, 430 cancer deaths were identified.
resultsAfter adjusting for sex, age, education, smoking status, drinking status, and body mass index, participants with diabetes at baseline showed an increased risk of gastric (HR 4.09; 95% CI 1.42-11.79), hepatocellular (HR 2.94; 95% CI 1.17-7.40), and prostate cancer mortality (HR 3.10; 95% CI 1.22-7.94). Further adjustment for arsenic exposure showed a significantly increased risk of all-cause cancer mortality with diabetes (HR 1.27; 95% CI 1.03-1.58). Insulin resistance among participants without diabetes at baseline was associated with hepatocellular cancer mortality (HR 4.70; 95% CI 1.55-14.26).
conclusionsDiabetes mellitus, and/or insulin resistance among those without diabetes, is a risk factor for gastric, hepatocellular, and prostate cancer in these American Indian communities, although relatively small sample size suggests cautious interpretation. Additional research is needed to evaluate the role of diabetes and obesity on cancer incidence in American Indian communities as well as the importance of diabetes prevention and control in reducing the burden of cancer incidence and mortality in the study population.
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