ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2016
RND1 is up-regulated in esophageal squamous cell carcinoma and promotes the growth and migration of cancer cells.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Profiling Ten RHO GTPases in Myeloid Malignancies Reveals Distinct Expression Patterns and Prognostic Associations.Cancer medicine · 2026Article
- Decoding Rho GTPase signalling networks in directed cell migration.Frontiers in cell and developmental biology · 2026Review
- FOXA2 Activates RND1 to Regulate Arachidonic Acid Metabolism Pathway and Suppress Cisplatin Resistance in Lung Squamous Cell Carcinoma.The clinical respiratory journal · 2024Article
- Molecular basis and current insights of atypical Rho small GTPase in cancer.Molecular biology reports · 2024Review
- The RND1 Small GTPase: Main Functions and Emerging Role in Oncogenesis.International journal of molecular sciences · 2019Review
- Article
- Pathophysiological functions of Rnd proteins.Small GTPasesReview
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RND1 is reported to control the dynamics of cytoskeleton, cell growth, and survival, and dysregulation of RND1 is involved in the tumorigenesis. However, its expression and functions in the esophageal squamous cell carcinoma (ESCC) are unknown. In the present study, it was found that the expression of RND1 was up-regulated in ESCC tissues compared with the adjacent normal tissues. Forced expression of RND1 promoted the growth and migration of ESCC cells, while knocking down the expression of RND1 inhibited the growth, migration, and metastasis of ESCC cells. Molecular mechanism studies showed that RND1 activated ERK signaling. In summary, our study suggested that RND1 plays an important role in the progression of ESCC, and RND1 might be a promising target for the treatment of ESCC.
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