ArticleThe world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry2015
Genetic underpinnings of left superior temporal gyrus thickness in patients with schizophrenia.
Article in The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Identification of genetic loci affecting body mass index through interaction with multiple environmental factors using structured linear mixed model.Scientific reports · 2021Trial
- Clinical application of sparse canonical correlation analysis to detect genetic associations with cortical thickness in Alzheimer's disease.Frontiers in neuroscience · 2024Article
- Article
- Effects of Vitamin D Use on Outcomes of Psychotic Symptoms in Alzheimer Disease Patients.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2019Article
- The metabolic basis of cognitive insight in psychosis: A positron emission tomography study.PloS one · 2017Article
- Balanced translocation linked to psychiatric disorder, glutamate, and cortical structure/function.NPJ schizophrenia · 2016Article
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Authors and funding
11 authors.
Funding
Abstract
objectivesSchizophrenia is a highly disabling psychiatric disorder with a heterogeneous phenotypic appearance. We aimed to further the understanding of some of the underlying genetics of schizophrenia, using left superior temporal gyrus (STG) grey matter thickness reduction as an endophenoptype in a genome-wide association (GWA) study.
methodsStructural magnetic resonance imaging (MRI) and genetic data of the Mind Clinical Imaging Consortium (MCIC) study of schizophrenia were used to analyse the interaction effects between 1,067,955 single nucleotide polymorphisms (SNPs) and disease status on left STG thickness in 126 healthy controls and 113 patients with schizophrenia. We next used a pathway approach to detect underlying pathophysiological pathways that may be related to schizophrenia.
resultsNo SNP by diagnosis interaction effect reached genome-wide significance (5 × 10
conclusionsOur strongest findings in the GWA study and pathway analysis point towards an involvement of glucose metabolism in left STG thickness reduction in patients with schizophrenia only. These results are in line with recently published studies, which showed an increased prevalence of psychosis among patients with metabolic syndrome-related illnesses including diabetes.
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Registered trials
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