ArticleDiagnostic pathology2015
Association between interleukin 8-251 T/A and +781 C/T polymorphisms and glioma risk.
Article in Diagnostic pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Genetic Variants Impacting Angiogenesis Signaling Pathways in Glioblastoma Multiforme: A Systematic Review of Mutations and Polymorphisms.Current molecular medicine · 2024Pooled it
- Weak association between the interleukin-8 rs4073 polymorphism and acute pancreatitis: a cumulative meta-analysis.BMC medical genetics · 2019Pooled it
- Proinflammatory Cytokine Gene Polymorphisms in Bullous Pemphigoid.Frontiers in immunology · 2019Trial
- Genetic Variants of Interleukin-8 and Interleukin-16 and Their Association with Cervical Cancer Risk.Life (Basel, Switzerland) · 2025Article
- The Association Between IL-8 Gene Polymorphisms and the Risk of Several Types of Cancer, Especially in Gastric Cancer.Cancer reports (Hoboken, N.J.) · 2025Article
- Review
- Article
- Association of Genetic Polymorphisms and Serum Levels of IL-6 and IL-8 with the Prognosis in Children with Neuroblastoma.Cancers · 2021Article
- A preliminary study of cytokine gene polymorphism effects on Saudi patients with colorectal cancer.Saudi medical journal · 2020Article
- Predicting the functional consequences of non-synonymous single nucleotide polymorphisms in IL8 gene.Scientific reports · 2017Article
- IL-8 -251A/T and +781C/T polymorphisms were associated with risk of breast cancer in a Chinese population.International journal of clinical and experimental pathology · 2017Article
- The associations between common SNPs ofOncoTargets and therapy · 2017Article
- Association between interleukin 8 -251 A/T and +781 C/T polymorphisms and osteosarcoma risk in Chinese population: a case-control study.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGliomas are aggressive tumors of the central nervous system that rely on production of growth factors for tumor progression. Interleukin 8 (IL-8) is up-regulated in gliomas to promote angiogenesis and proliferation. The aim of this study was to evaluate the association of the IL-8 -251 T/A and +781 C/T polymorphisms and glioma risk.
methodsWe enrolled 300 glioma patients and 300 age- and gender-matched healthy controls. A prospective hospital-based case-control design and logistic regression analysis were utilized. The IL-8 gene polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
resultsGlioma patients had a significantly higher frequency of IL-8 -251 AA genotype [odds ratio (OR) =1.91, 95% confidence interval (CI) = 1.22, 3.00; P = 0.005] and IL-8 -251 A allele (OR =1.36, 95% CI = 1.08, 1.70; P = 0.009) than controls. When stratified by the grade of glioma, patients with WHO IV glioma had a significantly higher frequency of IL-8 -251 AA genotype (OR =1.56, 95% CI = 1.01, 2.39; P = 0.04).
conclusionsTo the best of our knowledge, this is the first report in the literature that the IL-8 -251 AA genotype and A allele were at a higher risk for glioma.
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