ArticleHuman brain mapping2015
Differential functional brain network connectivity during visceral interoception as revealed by independent component analysis of fMRI TIME-series.
Article in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- Annual Research Review: Neural mechanisms of eating disorders in youth - from current theory and findings to future directions.Journal of child psychology and psychiatry, and allied disciplines · 2026Review
- Ventromedial prefrontal cortex attenuates the link between physiological heart rate reactions to unfairness and value computations in normative decision making.Social cognitive and affective neuroscience · 2026Article
- Disrupted prefrontal-sensorimotor functional connectivity mediates the association between depression and symptom severity in patients with irritable bowel syndrome.Frontiers in human neuroscience · 2026Article
- Distinct information flows for different whole-body actions across LOTC subdivisions.Communications biology · 2025Article
- A sensation driven functional MRI study on brain activation during bladder filling in healthy participants.Scientific reports · 2025Article
- Abnormal Cerebral Perfusion and Functional Connectivity in Women with Overactive Bladder.Brain sciences · 2025Article
- Changes in Brain Activity and Functional Connectivity During Spinal Nerve Stimulation in a Rat Model of Overactive Bladder.International neurourology journal · 2025Article
- Relationship Between Interoception and Autistic Traits: A Resting-State Functional Connectivity Study.Journal of autism and developmental disorders · 2024Article
- Brain Responses Difference between Sexes for Strong Desire to Void: A Functional Magnetic Resonance Imaging Study in Adults Based on Graph Theory.Journal of clinical medicine · 2024Article
- The effect of the apolipoprotein E ε4 allele and olfactory function on odor identification networks.Brain and behavior · 2024Article
- Relationship between functional connectivity and weight-gain risk of antipsychotics in schizophrenia.Schizophrenia research · 2024Article
- Cough Sensitivity to Several External Triggers is Associated with Multiple Non-respiratory Symptoms.Lung · 2023Article
- How brain diseases affect the lower urinary tract function?Bladder (San Francisco, Calif.) · 2023Review
- Article
- Relationships between interoceptive sensibility and resting-state functional connectivity of the insula in obsessive-compulsive disorder.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Functional brain imaging and central control of the bladder in health and disease.Frontiers in physiology · 2022Review
- Atypical interoception as a common risk factor for psychopathology: A review.Neuroscience and biobehavioral reviews · 2021Review
- Responses of functional brain networks to bladder control in healthy adults: a study using regional homogeneity combined with independent component analysis methods.International urology and nephrology · 2021Article
- Impact of Intravesical Cold Sensation on Functional Network Connectivity Estimated Using ICA at Rest & During Interoceptive Task.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2020Article
- The Central Autonomic Network and Regulation of Bladder Function.Frontiers in neuroscience · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Influential theories of brain-viscera interactions propose a central role for interoception in basic motivational and affective feeling states. Recent neuroimaging studies have underlined the insula, anterior cingulate, and ventral prefrontal cortices as the neural correlates of interoception. However, the relationships between these distributed brain regions remain unclear. In this study, we used spatial independent component analysis (ICA) and functional network connectivity (FNC) approaches to investigate time course correlations across the brain regions during visceral interoception. Functional magnetic resonance imaging (fMRI) was performed in thirteen healthy females who underwent viscerosensory stimulation of bladder as a representative internal organ at different prefill levels, i.e., no prefill, low prefill (100 ml saline), and high prefill (individually adapted to the sensations of persistent strong desire to void), and with different infusion temperatures, i.e., body warm (∼37°C) or ice cold (4-8°C) saline solution. During Increased distention pressure on the viscera, the insula, striatum, anterior cingulate, ventromedial prefrontal cortex, amygdalo-hippocampus, thalamus, brainstem, and cerebellar components showed increased activation. A second group of components encompassing the insula and anterior cingulate, dorsolateral prefrontal and posterior parietal cortices and temporal-parietal junction showed increased activity with innocuous temperature stimulation of bladder mucosa. Significant differences in the FNC were found between the insula and amygdalo-hippocampus, the insula and ventromedial prefrontal cortex, and the ventromedial prefrontal cortex and temporal-parietal junction as the distention pressure on the viscera increased. These results provide new insight into the supraspinal processing of visceral interoception originating from an internal organ.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.