Evidence map›Paper›PMID 26249266›Full record

ArticleDrug and alcohol dependence2015

Impaired learning from errors in cannabis users: Dorsal anterior cingulate cortex and hippocampus hypoactivity.

Susan E Carey, Liam Nestor, Jennifer Jones, Hugh Garavan, Robert Hester

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug and alcohol dependence, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 3 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 45 citations in OpenAlex.

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  9. A salience misattribution model for addictive-like behaviors.Neuroscience and biobehavioral reviews · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Susan E CareySchool of Psychological Sciences, University of Melbourne, Melbourne, Victoria, Australia.
Liam NestorSchool of Psychology and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Jennifer JonesSchool of Psychology and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Hugh GaravanSchool of Psychology and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland; Departments of Psychiatry and Psychology, University of Vermont, USA.
Robert HesterSchool of Psychological Sciences, University of Melbourne, Melbourne, Victoria, Australia. Electronic address: hesterr@unimelb.edu.au.
The University of Melbourne · AUTrinity College Dublin · IEUniversity of Vermont · US

Funding

Executive functions in cannabis dependenceR03DA018685 · NIDA · UNIVERSITY OF DUBLIN TRINITY COLLEGE · PI HESTER, ROBERT · 2004 to 2004
$162k
NIDA NIH HHS DA01865-01NIDA NIH HHS R03 DA018685
6 · The paper itself

Abstract

backgroundThe chronic use of cannabis has been associated with error processing dysfunction, in particular, hypoactivity in the dorsal anterior cingulate cortex (dACC) during the processing of cognitive errors. Given the role of such activity in influencing post-error adaptive behaviour, we hypothesised that chronic cannabis users would have significantly poorer learning from errors.

methodsFifteen chronic cannabis users (four females, mean age=22.40 years, SD=4.29) and 15 control participants (two females, mean age=23.27 years, SD=3.67) were administered a paired associate learning task that enabled participants to learn from their errors, during fMRI data collection.

resultsCompared with controls, chronic cannabis users showed (i) a lower recall error-correction rate and (ii) hypoactivity in the dACC and left hippocampus during the processing of error-related feedback and re-encoding of the correct response. The difference in error-related dACC activation between cannabis users and healthy controls varied as a function of error type, with the control group showing a significantly greater difference between corrected and repeated errors than the cannabis group.

conclusionsThe present results suggest that chronic cannabis users have poorer learning from errors, with the failure to adapt performance associated with hypoactivity in error-related dACC and hippocampal regions. The findings highlight a consequence of performance monitoring dysfunction in drug abuse and the potential consequence this cognitive impairment has for the symptom of failing to learn from negative feedback seen in cannabis and other forms of dependence.

Indexed as

AdultCase-Control StudiesCognition DisordersFemaleFunctional NeuroimagingGyrus CinguliHippocampusHumansLearningMagnetic Resonance ImagingMaleMarijuana SmokingYoung AdultAddictionCannabisDorsal anterior cingulate cortexDrug addictionfMRI

Identifiers

PMID26249266
PMCPMC4581978
OpenAlexW1960224492

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.