Evidence map›Paper›PMID 26249265›Full record

ArticleDrug and alcohol dependence2015

Cortical thinness and volume differences associated with marijuana abuse in emerging adults.

Y Mashhoon, S Sava, J T Sneider, L D Nickerson, M M Silveri

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug and alcohol dependence, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 4 pooled it
4.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 4 syntheses or guidelines pooled it, 52 citations in OpenAlex.

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  18. The Interplay between the Endocannabinoid System, Epilepsy and Cannabinoids.International journal of molecular sciences · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Y MashhoonBehavioral Psychopharmacology Research Laboratory, McLean Hospital, Belmont, MA, USA; McLean Imaging Center, McLean Hospital, Belmont, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA. Electronic address: ymashhoon@mclean.harvard.edu.
S SavaNeurodevelopmental Laboratory on Addictions and Mental Health, McLean Hospital, Belmont, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Boston VA Healthcare System, Brockton, MA, USA; Harvard South Shore Residency Program, Brockton, MA, USA.
J T SneiderNeurodevelopmental Laboratory on Addictions and Mental Health, McLean Hospital, Belmont, MA, USA; McLean Imaging Center, McLean Hospital, Belmont, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
L D NickersonBehavioral Psychopharmacology Research Laboratory, McLean Hospital, Belmont, MA, USA; McLean Imaging Center, McLean Hospital, Belmont, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
M M SilveriNeurodevelopmental Laboratory on Addictions and Mental Health, McLean Hospital, Belmont, MA, USA; McLean Imaging Center, McLean Hospital, Belmont, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
McLean Hospital · USHarvard University · USImaging Center · USVA Boston Healthcare System · US

Funding

Early Onset Cigarette smoking effects on brain structure, function and chemistryK01DA034028 · NIDA · MCLEAN HOSPITAL · PI MASHHOON, YASMIN · 2012 to 2016
$712k
Multi-modal MRI data fusion to assess neurobiological effects of marijuana useR01DA037265 · NIDA · MCLEAN HOSPITAL · PI NICKERSON, LISA D · 2014 to 2016
$705k
Neurocognition, Brain GABA &Adolescent Alcohol UseK01AA014651 · NIAAA · MC LEAN HOSPITAL (BELMONT, MA) · PI SILVERI, MARISA M · 2004 to 2008
$536k
fMRI of Hippocampal Function in Cannabis UsersR03DA022482 · NIDA · MCLEAN HOSPITAL · PI SNEIDER, JENNIFER TROPP · 2007 to 2007
$199k
NIAAA NIH HHS K01 AA014651NIAAA NIH HHS K01AA014651NIDA NIH HHS K01 DA034028NIDA NIH HHS K01DA034028NIDA NIH HHS R01 DA037265NIDA NIH HHS R01DA037265NIDA NIH HHS R03 DA022482NIDA NIH HHS R03DA022482
6 · The paper itself

Abstract

backgroundThe prevalence of marijuana (MJ) use among youth and its legalization for medical or recreational use has intensified public health endeavors of understanding MJ effects on brain structure and function. Studies indicate that MJ use is related to impaired cognitive performance, and altered functional brain activation and chemistry in adolescents and adults, but MJ effects on brain morphology in emerging adults are less understood.

methodsFifteen MJ users (age 21.8±3.6, 2 females) and 15 non-user (NU) participants (age 22.3±3.5, 2 females) were included, demographically matched on age, education and alcohol use. High-resolution structural MR images were acquired at 3Tesla. Cortical thickness (CT) and volumetric analyses were performed using Freesurfer. A priori regions of interest (ROI) included orbitofrontal and cingulate cortices, amygdala, hippocampus and thalamus.

resultsWhole brain CT analysis did not result in significant group differences in a priori ROIs but revealed MJ users had significantly less CT (i.e., thinness) in right fusiform gyrus (rFG) compared to NU (p<0.05). Thalamic volume was significantly smaller in MJ users compared to NU (right, p=0.05; left, p=0.01) and associated with greater non-planning (p<0.01) and overall impulsivity (p=0.04). There were no other group differences.

conclusionsRFG cortical thinness and smaller thalamic volume in emerging adults is associated with MJ abuse. Furthermore, smaller thalamic volume associated with greater impulsivity contributes to growing evidence that the thalamus is neurobiologically perturbed by MJ use. Collectively, altered thalamic and rFG structural integrity may interfere with their known roles in regulating visuoperceptual and object information processing.

Indexed as

AdolescentAdultAmygdalaAtrophyCannabisCase-Control StudiesCerebral CortexCognition DisordersFemaleHippocampusHumansImpulsive BehaviorMagnetic Resonance ImagingMaleMarijuana AbuseNeuroimagingCortical thicknessFusiform gyrusMarijuanaThalamusVolumeYoung adults

Identifiers

PMID26249265
PMCPMC4581973
OpenAlexW1750341761

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.