Evidence map›Paper›PMID 26249127›Full record

ArticleJournal of the International AIDS Society2015

HIV sexual transmission risks in the context of clinical care: a prospective study of behavioural correlates of HIV suppression in a community sample, Atlanta, GA, USA.

Seth C Kalichman, Chauncey Cherry, Moira O Kalichman, Christopher Washington, Tamar Grebler, Cindy Merely, Brandi Welles, Jennifer Pellowski, Christopher Kegler

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the International AIDS Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Seth C KalichmanDepartment of Psychology and Center for Health Intervention and Prevention, University of Connecticut, Storrs, CT, USA; seth.k@uconn.edu.
Chauncey CherryDepartment of Psychology and Center for Health Intervention and Prevention, University of Connecticut, Storrs, CT, USA.
Moira O KalichmanDepartment of Psychology and Center for Health Intervention and Prevention, University of Connecticut, Storrs, CT, USA.
Christopher WashingtonDepartment of Psychology and Center for Health Intervention and Prevention, University of Connecticut, Storrs, CT, USA.
Tamar GreblerDepartment of Psychology and Center for Health Intervention and Prevention, University of Connecticut, Storrs, CT, USA.
Cindy MerelyDepartment of Psychology and Center for Health Intervention and Prevention, University of Connecticut, Storrs, CT, USA.
Brandi WellesDepartment of Psychology and Center for Health Intervention and Prevention, University of Connecticut, Storrs, CT, USA.
Jennifer PellowskiDepartment of Psychology and Center for Health Intervention and Prevention, University of Connecticut, Storrs, CT, USA.
Christopher KeglerDepartment of Psychology and Center for Health Intervention and Prevention, University of Connecticut, Storrs, CT, USA.
University of Connecticut · USZero to Three · US

Funding

Behavioral Intervention to Enhance HIV Test/TreatR01DA033067 · NIDA · UNIVERSITY OF CONNECTICUT STORRS · PI KALICHMAN, SETH C · 2012 to 2016
$3.3M
Nurse Delivered Cell-Phone HIV Adherence InterventionR01NR012962 · NINR · UNIVERSITY OF CONNECTICUT STORRS · PI KALICHMAN, SETH C · 2011 to 2015
$2.6M
Influence of Food Insecurity on AdherenceR01AA021471 · NIAAA · UNIVERSITY OF CONNECTICUT STORRS · PI KALICHMAN, SETH C · 2013 to 2015
$941k
NIAAA NIH HHS R01-AA021471NIDA NIH HHS R0-DA033067NINR NIH HHS R01-NR012962
6 · The paper itself

Abstract

introductionAntiretroviral therapy (ART) improves the health of people living with HIV and has the potential to reduce HIV infectiousness, thereby preventing HIV transmission. However, the success of ART for HIV prevention hinges on sustained ART adherence and avoiding sexually transmitted infections (STI).

objectivesTo determine the sexual behaviours and HIV transmission risks of individuals with suppressed and unsuppressed HIV replication (i.e., viral load).

methodsAssessed HIV sexual transmission risks among individuals with clinically determined suppressed and unsuppressed HIV. Participants were 760 men and 280 women living with HIV in Atlanta, GA, USA, who completed behavioural assessments, 28-daily prospective sexual behaviour diaries, one-month prospective unannounced pill counts for ART adherence, urine screening for illicit drug use and medical record chart abstraction for HIV viral load.

resultsIndividuals with unsuppressed HIV demonstrated a constellation of behavioural risks for transmitting HIV to uninfected sex partners that included symptoms of STI and substance use. In addition, 15% of participants with suppressed HIV had recent STI symptoms/diagnoses, indicating significant risks for sexual infectiousness despite their HIV suppression in blood plasma. Overall, 38% of participants were at risk for elevated sexual infectiousness and just as many engaged in unprotected sexual intercourse with non-HIV-infected partners.

conclusionsImplementation strategies for using HIV treatments as HIV prevention requires enhanced behavioural interventions that extend beyond ART to address substance use and sexual health that will otherwise undermine the potential preventive impact of early ART.

Indexed as

Sexual BehaviorAdultFemaleHealth StatusHIV InfectionsHumansMaleMiddle AgedProspective StudiesRisk-TakingSexually Transmitted DiseasesSubstance-Related DisordersHIV preventionHIV suppressionsexual HIV transmissiontreatment as prevention

Identifiers

PMID26249127
PMCPMC4528077
OpenAlexW1831366099

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.