Evidence map›Paper›PMID 26249043›Full record

ArticleHuman brain mapping2015

RAB2A Polymorphism impacts prefrontal morphology, functional connectivity, and working memory.

Jin Li, Bing Liu, Chuansheng Chen, Yue Cui, Liqing Shang, Yun Zhang, Chao Wang, Xiaolong Zhang, Qinghua He, Wen Zhang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. National science review · 2019
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jin LiBrainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
Bing LiuBrainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
Chuansheng ChenDepartment of Psychology and Social Behavior, University of California, Irvine, California.
Yue CuiBrainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
Liqing ShangKey Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, China.
Yun ZhangKey Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, China.
Chao WangKey Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, China.
Xiaolong ZhangBrainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
Qinghua HeFaculty of Psychology, Southwest University, Chongqing, 400715, China.
Wen ZhangKey Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, China.
Wenwei BiKey Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, China.
Tianzi JiangBrainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calbindin-containing γ-aminobutyric acid (GABA)ergic interneurons in the prefrontal cortex (PFC) have been found to play an important role in working memory (WM) and their malfunctions have been linked to psychiatric disorders. A recent genome-wide association and expression-SNP study indicated that the RAB2A gene was associated with the density of prefrontal calbindin-positive neurons, suggesting this gene may have a broader influence on prefrontal structure and function. Using multimodal MRI and behavioral tasks, the current study investigated the effect of RAB2A on prefrontal morphology, resting-state functional connectivity, and WM performance in a large sample of healthy Han Chinese subjects. Results showed that the RAB2A AGCAAA haplotype was associated with improved WM accuracy, increased cortical thickness in the left inferior frontal gyrus, and decreased functional connectivity between the left inferior frontal gyrus and the left dorsolateral PFC. Our findings provide consistent evidence supporting the effect of RAB2A on the structure and function of the PFC and related cognitive functions. These results should provide new insights into the neural mechanisms underlying the GABAergic genes' role in WM as well as its dysfunction.

Indexed as

AdultChinaConnectomeFemaleHaplotypesHumansMagnetic Resonance ImagingMaleMemory, Short-TermPolymorphism, GeneticPrefrontal Cortexrab2 GTP-Binding ProteinYoung Adultrab2 GTP-Binding Proteincortical thicknessfunctional connectivityRas-related protein Rab-2A (RAB2A)working memory

Identifiers

PMID26249043
PMCPMC6869184

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.