ArticleDiabetologia2015
Convergence in insulin resistance between very severely obese and lean women at the end of pregnancy.
Article in Diabetologia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 48 citations in OpenAlex.
- The conceptual framework for a combined food literacy and physical activity intervention to optimize metabolic health among women of reproductive age in urban Uganda.BMC public health · 2022Trial
- Maternal metabolic profiling across body mass index groups: An exploratory longitudinal study.Acta obstetricia et gynecologica Scandinavica · 2024Article
- Parity modulates impact of BMI and gestational weight gain on gut microbiota in human pregnancy.Gut microbes · 2023Article
- Maternal metabolic syndrome in pregnancy and child development at age 5: exploring mediating mechanisms using cord blood markers.BMC medicine · 2023Article
- Ethnic Disparities and Obesity Risk Factors in Pregnant Women: A Retrospective Observational Cohort Study.Nutrients · 2023Observational
- Article
- Longitudinal Metabolic Profiling of Maternal Obesity, Gestational Diabetes, and Hypertensive Pregnancy Disorders.The Journal of clinical endocrinology and metabolism · 2021Article
- Insulin Requirements and Carbohydrate to Insulin Ratio in Normal Weight, Overweight, and Obese Women With Type 1 Diabetes Under Pump Treatment During Pregnancy: A Lesson From Old Technologies.Frontiers in endocrinology · 2021Observational
- Higher Numbers of Pregnancies Associated With an Increased Prevalence of Gestational Diabetes Mellitus: Results From the Healthy Baby Cohort Study.Journal of epidemiology · 2020Article
- When and How Should Chinese Pregnant Women Exercise? A Longitudinal Study in China.International journal of environmental research and public health · 2019Article
- Consequences of being overweight or obese during pregnancy on diabetes in the offspring: a record linkage study in Aberdeen, Scotland.Diabetologia · 2019Article
- Experiences related to health promotion behaviors in overweight pregnant women: a qualitative study.Reproductive health · 2018Article
- Metabolic syndrome in pregnancy and risk for adverse pregnancy outcomes: A prospective cohort of nulliparous women.PLoS medicine · 2018Article
- Advances in assessing body composition during pregnancy.European journal of clinical nutrition · 2018Review
- Maternal lipids in pregnancy are associated with increased offspring cortisol reactivity in childhood.Psychoneuroendocrinology · 2017Article
- Programming of infant neurodevelopment by maternal obesity: potential role of maternal inflammation and insulin resistance.Asia Pacific journal of clinical nutrition · 2017Article
- Influence of maternal obesity on the long-term health of offspring.The lancet. Diabetes & endocrinology · 2017Review
- Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
aimsDisrupted intermediary metabolism may contribute to the adverse pregnancy outcomes in women with very severe obesity. Our aim was to study metabolism in such pregnancies.
methodsWe recruited a longitudinal cohort of very severely obese (n = 190) and lean (n = 118) glucose-tolerant women for anthropometric and metabolic measurements at early, mid and late gestation and postpartum. In case-control studies of very severely obese and lean women we measured glucose and glycerol turnover during low- and high-dose hyperinsulinaemic-euglycaemic clamps (HEC) at early and late pregnancy and in non-pregnant women (each n = 6-9) and body fat distribution by MRI in late pregnancy (n = 10/group).
resultsAlthough greater glucose, insulin, NEFA and insulin resistance (HOMA-IR), and greater weight and % fat mass (FM) was observed in very severely obese vs lean participants, the degree of worsening was attenuated in the very severely obese individuals with advancing gestation, with no difference in triacylglycerol (TG) concentrations between very severely obese and lean women at term. Enhanced glycerol production was observed in early pregnancy only in very severely obese individuals, with similar intrahepatic FM in very severely obese vs lean women by late gestation. Offspring from obese mothers were heavier (p = 0.04). CONCLUSIONS/
interpretationPregnancies complicated by obesity demonstrate attenuation in weight gain and insulin resistance compared with pregnancies in lean women. Increased glycerol production is confined to obese women in early pregnancy and obese and lean individuals have similar intrahepatic FM by term. When targeting maternal metabolism to treat adverse pregnancy outcomes, therapeutic intervention may be most effective applied early in pregnancy.
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