ReviewJournal of medical microbiology2015
Current concepts in the pathogenesis and treatment of chronic suppurative otitis media.
Review in Journal of medical microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 14 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
104 citing papers in PubMed, 14 syntheses or guidelines pooled it, 259 citations in OpenAlex.
- Antibiotics versus topical antiseptics for chronic suppurative otitis media.The Cochrane database of systematic reviews · 2025Pooled it
- Topical antibiotics with steroids for chronic suppurative otitis media.The Cochrane database of systematic reviews · 2025Pooled it
- Topical antibiotics for chronic suppurative otitis media.The Cochrane database of systematic reviews · 2025Pooled it
- Systemic antibiotics for chronic suppurative otitis media.The Cochrane database of systematic reviews · 2025Pooled it
- Topical versus systemic antibiotics for chronic suppurative otitis media.The Cochrane database of systematic reviews · 2025Pooled it
- Chronic Otitis Media in Patients with Chronic Rhinosinusitis: A Systematic Review.Medicina (Kaunas, Lithuania) · 2023Pooled it
- Dysregulation of immune response in otitis media.Expert reviews in molecular medicine · 2021Pooled it
- Topical versus systemic antibiotics for chronic suppurative otitis media.The Cochrane database of systematic reviews · 2021Pooled it
- Systemic antibiotics for chronic suppurative otitis media.The Cochrane database of systematic reviews · 2021Pooled it
- Topical antibiotics with steroids for chronic suppurative otitis media.The Cochrane database of systematic reviews · 2020Pooled it
- Antibiotics versus topical antiseptics for chronic suppurative otitis media.The Cochrane database of systematic reviews · 2020Pooled it
- Topical antibiotics for chronic suppurative otitis media.The Cochrane database of systematic reviews · 2020Pooled it
- Pooled it
- A Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2018 Update by the Infectious Diseases Society of America and the American Society for Microbiology.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Guideline
- Targeting Eustachian Tube Microenvironment: Probiotic Surfactant Utilization for Antimicrobial Peptide Secretion to Prevent Otitis Media.Probiotics and antimicrobial proteins · 2026Review
- Article
- Etiology and Clinical Characteristics of Conductive Hearing Loss at a Tertiary Hospital in Sudan.Cureus · 2026Article
- Tackling Biofilm-Forming Pathogens: A Challenge to Overcome in the Fight Against Infectious Diseases.Pathogens (Basel, Switzerland) · 2026Review
- Management of Acute Postoperative Infections Following Microtia Reconstruction With Costal Cartilage Grafts.Plastic and reconstructive surgery. Global open · 2026Article
- Efficacy and Safety of Fat Graft Myringoplasty Combined With Platelet-Rich Plasma for Managing Chronic Tympanic Membrane Perforations: A Systematic Review and Meta-Analysis.Clinical and experimental otorhinolaryngology · 2026Article
44 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
Otitis media (OM) is an inflammation of the middle ear associated with infection. Despite appropriate therapy, acute OM (AOM) can progress to chronic suppurative OM (CSOM) associated with ear drum perforation and purulent discharge. The effusion prevents the middle ear ossicles from properly relaying sound vibrations from the ear drum to the oval window of the inner ear, causing conductive hearing loss. In addition, the inflammatory mediators generated during CSOM can penetrate into the inner ear through the round window. This can cause the loss of hair cells in the cochlea, leading to sensorineural hearing loss. Pseudomonas aeruginosa and Staphylococcus aureus are the most predominant pathogens that cause CSOM. Although the pathogenesis of AOM is well studied, very limited research is available in relation to CSOM. With the emergence of antibiotic resistance as well as the ototoxicity of antibiotics and the potential risks of surgery, there is an urgent need to develop effective therapeutic strategies against CSOM. This warrants understanding the role of host immunity in CSOM and how the bacteria evade these potent immune responses. Understanding the molecular mechanisms leading to CSOM will help in designing novel treatment modalities against the disease and hence preventing the hearing loss.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.