ArticleNeurorehabilitation and neural repair2016
Cortical Stimulation Concurrent With Skilled Motor Training Improves Forelimb Function and Enhances Motor Cortical Reorganization Following Controlled Cortical Impact.
Article in Neurorehabilitation and neural repair, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Motor Recovery After a Hemispherectomy: Review of Mechanisms and the Potential of Neuromodulation to Enhance Motor Outcomes.Journal of child neurology · 2026Review
- Short-Term Cortical Electrical Stimulation during the Acute Stage of Traumatic Brain Injury Improves Functional Recovery.Biomedicines · 2022Article
- A multicenter, randomized, double-blind, placebo-controlled trial to test efficacy and safety of transcranial direct current stimulation to the motor cortex after stroke (NETS): study protocol.Neurological research and practice · 2022Article
- Cortical Electrical Stimulation Ameliorates Traumatic Brain Injury-Induced Sensorimotor and Cognitive Deficits in Rats.Frontiers in neural circuits · 2021Article
- Neurostimulation and Reach-to-Grasp Function Recovery Following Acquired Brain Injury: Insight From Pre-clinical Rodent Models and Human Applications.Frontiers in neurology · 2020Review
- Enhancing rehabilitation and functional recovery after brain and spinal cord trauma with electrical neuromodulation.Current opinion in neurology · 2019Review
- Cathodal Transcranial Direct-Current Stimulation Selectively Decreases Impulsivity after Traumatic Brain Injury in Rats.Journal of neurotrauma · 2019Article
- Transcranial direct current stimulation for the treatment of motor impairment following traumatic brain injury.Journal of neuroengineering and rehabilitation · 2019Review
- Focal traumatic brain injury induces neuroplastic molecular responses in lumbar spinal cord.Restorative neurology and neuroscience · 2019Article
- Traumatic Brain Injury Occludes Training-Dependent Cortical Reorganization in the Contralesional Hemisphere.Journal of neurotrauma · 2017Article
- Intra- and interregional coregulation of opioid genes: broken symmetry in spinal circuits.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Striatal Mitochondrial Disruption following Severe Traumatic Brain Injury.Journal of neurotrauma · 2017Article
- Understanding the Mechanisms of Recovery and/or Compensation following Injury.Neural plasticity · 2017Review
- Brain stimulation: Neuromodulation as a potential treatment for motor recovery following traumatic brain injury.Brain research · 2016Review
- Combinatorial Motor Training Results in Functional Reorganization of Remaining Motor Cortex after Controlled Cortical Impact in Rats.Journal of neurotrauma · 2016Article
- Enhancing Rehabilitative Therapies with Vagus Nerve Stimulation.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2016Review
- Restoring Behavior via Inverse Neurocontroller in a Lesioned Cortical Spiking Model Driving a Virtual Arm.Frontiers in neuroscience · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundElectrical and magnetic brain stimulation can improve motor function following stroke in humans, rats, and nonhuman primates, especially when paired with rehabilitative training (RT). Previously, we found in rodent stroke models that epidural electrical cortical stimulation (CS) of the ipsilesional motor cortex (MC) combined with motor RT enhances motor function and motor cortical plasticity. It was unknown whether CS following experimental traumatic brain injury (TBI) would have similar effects.
objectiveTo test the effects of CS combined with motor training after moderate/severe TBI on behavioral outcome and motor cortical organization.
methodsFollowing unilateral controlled cortical impact (CCI) over the caudal forelimb area of the MC in adult male rats, forelimb reach training was administered daily for 9 weeks concurrently with subthreshold, 100-Hz monopolar CS or no-stimulation control procedures. The rate and magnitude of behavioral improvements and changes in forelimb movement representations in the injured MC as revealed by intracortical microstimulation were measured.
resultsCCI resulted in severe motor impairments persisting throughout the 9 weeks of training in both groups, but CS-treated animals had significantly greater behavioral improvements. CS also increased wrist motor cortical representation, one of the main movements used in the training task, when compared with RT alone. However, the overall recovery level was modest, leaving animals still extremely impaired.
conclusionsThese data suggest that CS may be useful for improving rehabilitation efficacy after TBI but also raise the possibility that the CS parameters that are highly effective following stroke are suboptimal after moderate/severe TBI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.