Evidence map›Paper›PMID 26248482›Full record

SynthesisNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2015

Inverse relationship between cancer and Alzheimer's disease: a systemic review meta-analysis.

Qinghua Zhang, Shougang Guo, Xiao Zhang, Shi Tang, Wen Shao, Xiaojuan Han, Lu Wang, Yifeng Du

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 71 citations in OpenAlex.

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  8. The inverse association between cancer history and incident cognitive impairment: Addressing attrition bias.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Qinghua ZhangDepartment of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, People's Republic of China.
Shougang GuoDepartment of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, People's Republic of China.
Xiao ZhangDepartment of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, People's Republic of China.
Shi TangDepartment of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, People's Republic of China.
Wen ShaoDepartment of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, People's Republic of China.
Xiaojuan HanDepartment of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, People's Republic of China.
Lu WangDepartment of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, People's Republic of China.
Yifeng DuDepartment of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, People's Republic of China. neurology2014@163.com.
Shandong Provincial Hospital · CNShandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) and cancer are both prevalent in the elderly. Some epidemiological researches have reported the negative association between AD and cancer, but the results are controversial. The present meta-analysis is aimed to clarify the association between cancer and AD. PubMed, Web of knowledge and the Cochrane library databases were searched for eligible publications. The analysis indicated that history of cancer was associated with a reduced risk of AD (ES 0.62, 95 % CIs 0.53-0.74; p < 0.001), with no significance between-study heterogeneity and publication bias. Similar results were found in subgroup analysis by stratifying variables with education and APOEε4 carriers, years of follow-up and sample size of cases. The negative association was also found in analysis of risk of cancer among patients with AD (ES 0.59, 95 % CIs 0.42-0.82; p = 0.002), but with evidence of between-study heterogeneity and publication bias. In order to identify sources of the heterogeneity, subgroup analysis was performed by stratifying variable with or without education adjusted, sample size of cases and years of follow-up. Negative association was found in all subgroup analysis except in studies with less than 5-year follow-up and with heterogeneity disappeared only in the subgroup analysis stratified with sample size of cases. Our results in the present meta-analysis support the negative association between AD and cancer. But further well-designed perspective studies with strict control of confounding factors are needed to clarify the association between AD and cancer.

Indexed as

Alzheimer DiseaseHumansNeoplasmsAlzheimer’s diseaseCancerMeta-analysis

Identifiers

PMID26248482
OpenAlexW1096808295

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.