Evidence map›Paper›PMID 26248333›Full record

ArticleClinical immunology (Orlando, Fla.)2015

Combined immunodeficiency in the United States and Kuwait: Comparison of patients' characteristics and molecular diagnosis.

Waleed Al-Herz, Luigi D Notarangelo, Ali Sadek, Rebecca Buckley, USIDNET Consortium

Abstract read
In one paragraph

Article in Clinical immunology (Orlando, Fla.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Trial
  2. Article
  3. Morbidity, Mortality, and Therapeutics in Combined Immunodeficiency: Data From the USIDNET Registry.The journal of allergy and clinical immunology. In practice · 2022
    Article
  4. Imaging Features of Primary Immunodeficiency Disorders.Radiology. Cardiothoracic imaging · 2021
    Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Waleed Al-HerzDepartment of Pediatrics, Faculty of Medicine, Kuwait University, Kuwait; Allergy & Clinical Immunology Unit, Pediatric Department, Al-Sabah Hospital, Kuwait. Electronic address: wemh@hotmail.com.
Luigi D NotarangeloDivision of Immunology, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical School, Boston, MA, United States.
Ali SadekKuwait National Center for Health information, Kuwait.
Rebecca BuckleyDepartments of Pediatrics and Immunology, Duke University Medical Center, Durham, NC, United States.
USIDNET Consortium

Funding

Regulation of IgA class switching in the intestinal mucosaP01AI061093 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI CUNNINGHAM-RUNDLES, CHARLOTTE · 2004 to 2021
$29.8M
Resources to Assist Investigations in Primary Immunodeficiency Diseases (U24)U24AI086037 · NIAID · IMMUNE DEFICIENCY FOUNDATION · PI CUNNINGHAM-RUNDLES, CHARLOTTE · 2010 to 2019
$6.5M
TARGETING PRIMARY IMMUNODEFICIENCY AMONG MINORITIESR18AI048693 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI CUNNINGHAM-RUNDLES, CHARLOTTE · 2000 to 2016
$6.2M
NIAID NIH HHS P01 AI061093NIAID NIH HHS R18 AI048693NIAID NIH HHS U24 AI086037
6 · The paper itself

Abstract

aimTo compare different variables among (S)CID patients diagnosed in the USA and Kuwait.

methodsReview of patients registered in The US Immune Deficiency Network registry or Kuwait National PID Registry between 2004 and 2014.

resultsTotals of 98 and 69 (S)CID patients were registered during the study period in the USIDNET registry and the KNPIDR, respectively. The average annual incidence rate for the period 2004-2014 of (S)CID in children in Kuwait was 13.01/100,000 children, with an estimated occurrence of 1/7500 live births. There were differences between the two countries in the following variables: age at onset and diagnosis, family history of (S)CID, parental consanguinity, and outcome. More than 14% of (S)CID patients from USIDNET registry were diagnosed through newborn screening.

conclusionsPatients' characteristics and molecular causes of S(CID) are different between USA and Kuwait. NBS for SCID should be started in countries where the incidence of (S)CID is high.

Indexed as

Age of OnsetChildHumansImmunologic Deficiency SyndromesInfant, NewbornKuwaitNeonatal ScreeningPathology, MolecularRegistriesUnited StatesCombined immunodeficiencyEpidemiologyGeneticsIncidenceNewborn screeningPrevalenceRegistry

Identifiers

PMID26248333
PMCPMC4869855

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.