ArticleEndocrinology2015
FABP4-Cre Mediated Expression of Constitutively Active ChREBP Protects Against Obesity, Fatty Liver, and Insulin Resistance.
Article in Endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Glucose-Sensing Carbohydrate Response Element-Binding Protein in the Pathogenesis of Diabetic Retinopathy.Cells · 2025Article
- Mondo family proteins in diabetes.Frontiers in endocrinology · 2025Review
- Glucose-Sensing ChREBP Protein in the Pathogenesis of Dia-betic Retinopathy.bioRxiv : the preprint server for biology · 2024Article
- The role of ChREBP in carbohydrate sensing and NAFLD development.Nature reviews. Endocrinology · 2023Review
- The Function of MondoA and ChREBP Nutrient-Sensing Factors in Metabolic Disease.International journal of molecular sciences · 2023Review
- Genipin Attenuates Diabetic Cognitive Impairment by Reducing Lipid Accumulation and Promoting Mitochondrial Fusion via FABP4/Mfn1 Signaling in Microglia.Antioxidants (Basel, Switzerland) · 2022Article
- Visualization and quantification ofAnnals of translational medicine · 2022Article
- Article
- MED1 is a lipogenesis coactivator required for postnatal adipose expansion.Genes & development · 2021Article
- Lipopolysaccharide-Induced Transcriptional Changes in LBP-Deficient Rat and Its Possible Implications for Liver Dysregulation during Sepsis.Journal of immunology research · 2021Article
- The Role of Mondo Family Transcription Factors in Nutrient-Sensing and Obesity.Frontiers in endocrinology · 2021Review
- The glucose-sensing transcription factor ChREBP is targeted by proline hydroxylation.The Journal of biological chemistry · 2020Article
- De Novo Lipogenesis as a Source of Second Messengers in Adipocytes.Current diabetes reports · 2019Review
- Glucose-Sensing Transcription Factor MondoA/ChREBP as Targets for Type 2 Diabetes: Opportunities and Challenges.International journal of molecular sciences · 2019Review
- Lyophilized Maqui (Antioxidants (Basel, Switzerland) · 2019Article
- SREBP-regulated adipocyte lipogenesis is dependent on substrate availability and redox modulation of mTORC1.JCI insight · 2019Article
- Adipokinome Signatures in Obese Mouse Models Reflect Adipose Tissue Health and Are Associated with Serum Lipid Composition.International journal of molecular sciences · 2019Article
- Naringenin Promotes Thermogenic Gene Expression in Human White Adipose Tissue.Obesity (Silver Spring, Md.) · 2019Article
- Regulation and Metabolic Significance ofNutrients · 2018Review
- Perilipin-2 deletion promotes carbohydrate-mediated browning of white adipose tissue at ambient temperature.Journal of lipid research · 2018Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Carbohydrate response element binding protein (ChREBP) regulates cellular glucose and lipid homeostasis. Although ChREBP is highly expressed in many key metabolic tissues, the role of ChREBP in most of those tissues and the consequent effects on whole-body glucose and lipid metabolism are not well understood. Therefore, we generated a transgenic mouse that overexpresses a constitutively active ChREBP isoform under the control of the fatty acid binding protein 4-Cre-driven promoter (FaChOX). Weight gain was blunted in male, but not female, FaChOX mice when placed on either a normal chow diet or an obesogenic Western diet. Respiratory exchange ratios were increased in Western diet-fed FaChOX mice, indicating a shift in whole-body substrate use favoring carbohydrate metabolism. Western diet-fed FaChOX mice showed improved insulin sensitivity and glucose tolerance in comparison with controls. Hepatic triglyceride content was reduced in Western diet-fed FaChOX mice in comparison with controls, suggesting protection from fatty liver. Epididymal adipose tissue exhibited differential expression of genes involved in differentiation, browning, metabolism, lipid homeostasis, and inflammation between Western diet-fed FaChOX mice and controls. Our findings support a role for ChREBP in modulating adipocyte differentiation and adipose tissue metabolism and inflammation as well as consequent risks for obesity and insulin resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.