Evidence map›Paper›PMID 26248216›Full record

ArticleEndocrinology2015

Exposure of Human Prostaspheres to Bisphenol A Epigenetically Regulates SNORD Family Noncoding RNAs via Histone Modification.

Shuk-Mei Ho, Ana Cheong, Hung-Ming Lam, Wen-Yang Hu, Guang-Bin Shi, Xuegong Zhu, Jing Chen, Xiang Zhang, Mario Medvedovic, Yuet-Kin Leung and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 53 citations in OpenAlex.

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  20. Estrogens in Male Physiology.Physiological reviews · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Shuk-Mei HoDepartment of Environmental Health (S.-M.H., A.C., H.-M.L., X.Zhu, J.C., X.Zha., M.M., Y.-K.L.), Center for Environmental Genetics (S.-M.H., A.C., H.-M.L., X.Zhu, J.C., X.Zha., M.M., Y.-K.L.), University of Cincinnati Medical Center, Cincinnati Cancer Center (S.-M.H., M.M., Y.-K.L.), Cincinnati, Ohio 45267; and Cincinnati Veteran Affairs Hospital Medical Center (S.-M.H.), Cincinnati, Ohio 45220; and Department of Urology (W.-Y.H., G.-B.S., G.S.P.), College of Medicine, and University of Illinois Cancer Center (W.-Y.H., G.-B.S., G.S.P.), University of Illinois at Chicago, Chicago, Illinois 60612.
Ana CheongDepartment of Environmental Health (S.-M.H., A.C., H.-M.L., X.Zhu, J.C., X.Zha., M.M., Y.-K.L.), Center for Environmental Genetics (S.-M.H., A.C., H.-M.L., X.Zhu, J.C., X.Zha., M.M., Y.-K.L.), University of Cincinnati Medical Center, Cincinnati Cancer Center (S.-M.H., M.M., Y.-K.L.), Cincinnati, Ohio 45267; and Cincinnati Veteran Affairs Hospital Medical Center (S.-M.H.), Cincinnati, Ohio 45220; and Department of Urology (W.-Y.H., G.-B.S., G.S.P.), College of Medicine, and University of Illinois Cancer Center (W.-Y.H., G.-B.S., G.S.P.), University of Illinois at Chicago, Chicago, Illinois 60612.
Hung-Ming LamDepartment of Environmental Health (S.-M.H., A.C., H.-M.L., X.Zhu, J.C., X.Zha., M.M., Y.-K.L.), Center for Environmental Genetics (S.-M.H., A.C., H.-M.L., X.Zhu, J.C., X.Zha., M.M., Y.-K.L.), University of Cincinnati Medical Center, Cincinnati Cancer Center (S.-M.H., M.M., Y.-K.L.), Cincinnati, Ohio 45267; and Cincinnati Veteran Affairs Hospital Medical Center (S.-M.H.), Cincinnati, Ohio 45220; and Department of Urology (W.-Y.H., G.-B.S., G.S.P.), College of Medicine, and University of Illinois Cancer Center (W.-Y.H., G.-B.S., G.S.P.), University of Illinois at Chicago, Chicago, Illinois 60612.
Wen-Yang HuDepartment of Environmental Health (S.-M.H., A.C., H.-M.L., X.Zhu, J.C., X.Zha., M.M., Y.-K.L.), Center for Environmental Genetics (S.-M.H., A.C., H.-M.L., X.Zhu, J.C., X.Zha., M.M., Y.-K.L.), University of Cincinnati Medical Center, Cincinnati Cancer Center (S.-M.H., M.M., Y.-K.L.), Cincinnati, Ohio 45267; and Cincinnati Veteran Affairs Hospital Medical Center (S.-M.H.), Cincinnati, Ohio 45220; and Department of Urology (W.-Y.H., G.-B.S., G.S.P.), College of Medicine, and University of Illinois Cancer Center (W.-Y.H., G.-B.S., G.S.P.), University of Illinois at Chicago, Chicago, Illinois 60612.
Guang-Bin ShiDepartment of Environmental Health (S.-M.H., A.C., H.-M.L., X.Zhu, J.C., X.Zha., M.M., Y.-K.L.), Center for Environmental Genetics (S.-M.H., A.C., H.-M.L., X.Zhu, J.C., X.Zha., M.M., Y.-K.L.), University of Cincinnati Medical Center, Cincinnati Cancer Center (S.-M.H., M.M., Y.-K.L.), Cincinnati, Ohio 45267; and Cincinnati Veteran Affairs Hospital Medical Center (S.-M.H.), Cincinnati, Ohio 45220; and Department of Urology (W.-Y.H., G.-B.S., G.S.P.), College of Medicine, and University of Illinois Cancer Center (W.-Y.H., G.-B.S., G.S.P.), University of Illinois at Chicago, Chicago, Illinois 60612.
Xuegong ZhuDepartment of Environmental Health (S.-M.H., A.C., H.-M.L., X.Zhu, J.C., X.Zha., M.M., Y.-K.L.), Center for Environmental Genetics (S.-M.H., A.C., H.-M.L., X.Zhu, J.C., X.Zha., M.M., Y.-K.L.), University of Cincinnati Medical Center, Cincinnati Cancer Center (S.-M.H., M.M., Y.-K.L.), Cincinnati, Ohio 45267; and Cincinnati Veteran Affairs Hospital Medical Center (S.-M.H.), Cincinnati, Ohio 45220; and Department of Urology (W.-Y.H., G.-B.S., G.S.P.), College of Medicine, and University of Illinois Cancer Center (W.-Y.H., G.-B.S., G.S.P.), University of Illinois at Chicago, Chicago, Illinois 60612.
Jing ChenDepartment of Environmental Health (S.-M.H., A.C., H.-M.L., X.Zhu, J.C., X.Zha., M.M., Y.-K.L.), Center for Environmental Genetics (S.-M.H., A.C., H.-M.L., X.Zhu, J.C., X.Zha., M.M., Y.-K.L.), University of Cincinnati Medical Center, Cincinnati Cancer Center (S.-M.H., M.M., Y.-K.L.), Cincinnati, Ohio 45267; and Cincinnati Veteran Affairs Hospital Medical Center (S.-M.H.), Cincinnati, Ohio 45220; and Department of Urology (W.-Y.H., G.-B.S., G.S.P.), College of Medicine, and University of Illinois Cancer Center (W.-Y.H., G.-B.S., G.S.P.), University of Illinois at Chicago, Chicago, Illinois 60612.
Xiang ZhangDepartment of Environmental Health (S.-M.H., A.C., H.-M.L., X.Zhu, J.C., X.Zha., M.M., Y.-K.L.), Center for Environmental Genetics (S.-M.H., A.C., H.-M.L., X.Zhu, J.C., X.Zha., M.M., Y.-K.L.), University of Cincinnati Medical Center, Cincinnati Cancer Center (S.-M.H., M.M., Y.-K.L.), Cincinnati, Ohio 45267; and Cincinnati Veteran Affairs Hospital Medical Center (S.-M.H.), Cincinnati, Ohio 45220; and Department of Urology (W.-Y.H., G.-B.S., G.S.P.), College of Medicine, and University of Illinois Cancer Center (W.-Y.H., G.-B.S., G.S.P.), University of Illinois at Chicago, Chicago, Illinois 60612.
Mario MedvedovicDepartment of Environmental Health (S.-M.H., A.C., H.-M.L., X.Zhu, J.C., X.Zha., M.M., Y.-K.L.), Center for Environmental Genetics (S.-M.H., A.C., H.-M.L., X.Zhu, J.C., X.Zha., M.M., Y.-K.L.), University of Cincinnati Medical Center, Cincinnati Cancer Center (S.-M.H., M.M., Y.-K.L.), Cincinnati, Ohio 45267; and Cincinnati Veteran Affairs Hospital Medical Center (S.-M.H.), Cincinnati, Ohio 45220; and Department of Urology (W.-Y.H., G.-B.S., G.S.P.), College of Medicine, and University of Illinois Cancer Center (W.-Y.H., G.-B.S., G.S.P.), University of Illinois at Chicago, Chicago, Illinois 60612.
Yuet-Kin LeungDepartment of Environmental Health (S.-M.H., A.C., H.-M.L., X.Zhu, J.C., X.Zha., M.M., Y.-K.L.), Center for Environmental Genetics (S.-M.H., A.C., H.-M.L., X.Zhu, J.C., X.Zha., M.M., Y.-K.L.), University of Cincinnati Medical Center, Cincinnati Cancer Center (S.-M.H., M.M., Y.-K.L.), Cincinnati, Ohio 45267; and Cincinnati Veteran Affairs Hospital Medical Center (S.-M.H.), Cincinnati, Ohio 45220; and Department of Urology (W.-Y.H., G.-B.S., G.S.P.), College of Medicine, and University of Illinois Cancer Center (W.-Y.H., G.-B.S., G.S.P.), University of Illinois at Chicago, Chicago, Illinois 60612.
Gail S PrinsDepartment of Environmental Health (S.-M.H., A.C., H.-M.L., X.Zhu, J.C., X.Zha., M.M., Y.-K.L.), Center for Environmental Genetics (S.-M.H., A.C., H.-M.L., X.Zhu, J.C., X.Zha., M.M., Y.-K.L.), University of Cincinnati Medical Center, Cincinnati Cancer Center (S.-M.H., M.M., Y.-K.L.), Cincinnati, Ohio 45267; and Cincinnati Veteran Affairs Hospital Medical Center (S.-M.H.), Cincinnati, Ohio 45220; and Department of Urology (W.-Y.H., G.-B.S., G.S.P.), College of Medicine, and University of Illinois Cancer Center (W.-Y.H., G.-B.S., G.S.P.), University of Illinois at Chicago, Chicago, Illinois 60612.
Center for Human Genetics · USUniversity of Illinois Chicago · USCincinnati Health Department · USUniversity of Cincinnati · US

Funding

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI PINNEY, SUSAN MENGEL · 1992 to 2022
$35.4M
Epigenetic Basis for Prostate Carcinogenesis following Early Estrogenic ExposuresR01ES015584 · NIEHS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI HO, SHUK-MEI, PRINS, GAIL S · 2008 to 2012
$3.1M
Susceptible Window of High Fat Diet/Bisphenol A Programming of Breast Cancer RiskU01ES019480 · NIEHS · UNIVERSITY OF CINCINNATI · PI HO, SHUK-MEI · 2010 to 2014
$2.2M
Developmental Reprogramming of Prostate Carcinogenesis by BPARC2ES018789 · NIEHS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI HO, SHUK-MEI, MANCINI, MICHAEL A. · 2009 to 2010
$1.9M
Developmental Exposure to Low-dose Bisphenol A and Human Prostate Cancer SusceptiRC2ES018758 · NIEHS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI HO, SHUK-MEI, PRINS, GAIL S · 2009 to 2010
$1.9M
Estrogen Receptors in Human Prostate Stem-Progenitor CellsR01CA172220 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI PRINS, GAIL S · 2013 to 2017
$1.7M
Chronic exposure to Biphenol A and uterine cancer risk markersU01ES020988 · NIEHS · UNIVERSITY OF CINCINNATI · PI HO, SHUK-MEI · 2011 to 2014
$796k
G-protein coupled receptor-30(GPR30):a putative new therapeutic target for PCaI01BX000675 · VA · CINCINNATI VA MEDICAL CENTER RESEARCH · PI HO, SHUK-MEI · 2011 to 2019
–
BLRD VA I01 BX000675NCI NIH HHS CA172220NCI NIH HHS R01 CA172220NIEHS NIH HHS P30 ES006096NIEHS NIH HHS P30ES006096NIEHS NIH HHS R01 ES015584NIEHS NIH HHS R01ES015584NIEHS NIH HHS RC2 ES018758NIEHS NIH HHS RC2ES018758NIEHS NIH HHS RC2 ES018789NIEHS NIH HHS RC2ES018789NIEHS NIH HHS U01 ES019480NIEHS NIH HHS U01ES019480NIEHS NIH HHS U01 ES020988NIEHS NIH HHS U01ES020988
6 · The paper itself

Abstract

Bisphenol A (BPA) is a ubiquitous endocrine disruptor exerting lifelong effects on gene expression in rodent prostate cancer (PCa) models. Here, we aimed to determine whether epigenetic events mediating the action of BPA on human prostaspheres enriched in epithelial stem-like/progenitor cells is linked to PCa. We performed genome-wide transcriptome and methylome analyses to identify changes in prostaspheres treated with BPA (10 nM, 200 nM, and 1000 nM) or estradiol-17β (E2) (0.1 nM) for 7 days and validated changes in expression, methylation, and histone marks in parallel-treated prostaspheres. BPA/E2-treatment altered expression of 91 genes but not the methylation status of 485,000 CpG sites in BPA/E2-treated prostaspheres. A panel of 26 genes was found repressed in all treatment groups. Fifteen of them were small nucleolar RNAs with C/D motif (SNORDs), which are noncoding, small nucleolar RNAs known to regulate ribosomal RNA assembly and function. Ten of the most down-regulated SNORDs were further studied. All 10 were confirmed repressed by BPA, but only 3 ratified as E2-repressed. SNORD suppression showed no correlation with methylation status changes in CpG sites in gene regulatory regions. Instead, BPA-induced gene silencing was found to associate with altered recruitments of H3K9me3, H3K4me3, and H3K27me3 to 5'-regulatory/exonic sequences of 5 SNORDs. Expression of 4 out of these 5 SNORDs (SNORD59A, SNORD82, SNORD116, and SNORD117) was shown to be reduced in PCa compared with adjacent normal tissue. This study reveals a novel and unique action of BPA in disrupting expression of PCa-associated SNORDs and a putative mechanism for reprogramming the prostasphere epigenome via histone modification.

Indexed as

Benzhydryl CompoundsBisphenol A CompoundsCluster AnalysisCpG IslandsDNA MethylationDose-Response Relationship, DrugEpigenesis, GeneticEpithelial CellsEstradiolEstrogensEstrogens, Non-SteroidalHistone CodeHistonesHumansLysineMaleBenzhydryl Compoundsbisphenol ABisphenol A CompoundsEstradiolEstrogensEstrogens, Non-SteroidalHistonesLysinePhenolsRNA, Untranslated

Identifiers

PMID26248216
PMCPMC4606748
OpenAlexW1807492903

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.