ArticleInternational journal of molecular sciences2015
Composition, Cytotoxic and Antimicrobial Activities of Satureja intermedia C.A.Mey Essential Oil.
Article in International journal of molecular sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 56 citations in OpenAlex.
- Current Knowledge of the GenusPharmaceuticals (Basel, Switzerland) · 2026Review
- The anticancer effects of thymol on HepG2 cell line.Medical oncology (Northwood, London, England) · 2023Article
- Review on Additives in Hydrogels for 3D Bioprinting of Regenerative Medicine: From Mechanism to Methodology.Pharmaceutics · 2023Review
- The Essential Oil fromPharmaceuticals (Basel, Switzerland) · 2022Article
- Nanoemulsions ofPharmaceutics · 2021Article
- Review
- In Vitro Evaluation of the Antimicrobial and Immunomodulatory Activity of Culinary Herb Essential Oils as Potential Perioceutics.Antibiotics (Basel, Switzerland) · 2020Article
- Phytochemical Analysis and Biological Investigation ofPlants (Basel, Switzerland) · 2020Article
- Article
- Cross-Linked Polymer-Stabilized Nanocomposites for the Treatment of Bacterial Biofilms.ACS nano · 2017Article
- Biological Activities of Essential Oils: From Plant Chemoecology to Traditional Healing Systems.Molecules (Basel, Switzerland) · 2017Review
- Antinociceptive and Anti-Inflammatory Activities of Teucrium persicum Boiss. Extract in Mice.Scientifica · 2015Article
- The antibacterial activity of "Dental research journalArticle
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, the essential oil (EO) constituents from the aerial parts of Satureja intermedia C.A.Mey were detected by GC and GC/MS. The antimicrobial activity of EO on oral pathogens and its cytotoxicity to human cancer cells were determined by the microbroth dilution method and the crystal violet staining method, respectively. Thirty-nine compounds were identified and the main EO constituents were γ-terpinene (37.1%), thymol (30.2%), p-cymene (16.2%), limonene (3.9%), α-terpinene (3.3%), myrcene (2.5%), germacrene B (1.4%), elemicine (1.1%) and carvacrol (0.5%). The S. intermedia EO showed a concentration-dependent decrease in viability of Hep-G2 (hepatocellular carcinoma) and MCF-7 (breast adenocarcinoma) human cancer cell lines (p < 0.05). Antimicrobial screening of S. intermedia EO demonstrated slight antibacterial and antifungal activities against Streptococcus mutants, S. salivarius, Enterococcus faecalis, Staphylococcus aureus, Candida albicans and C. glabrata. Further preclinical studies are needed to assess the efficacy and safety of S. intermedia EO as a new promising anticancer agent.
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