Evidence map›Paper›PMID 26247205›Full record

ArticlePloS one2015

Arginine Thiazolidine Carboxylate Stimulates Insulin Secretion through Production of Ca2+-Mobilizing Second Messengers NAADP and cADPR in Pancreatic Islets.

Dae-Ryoung Park, Asif Iqbal Shawl, Tae-Geun Ha, Kwang-Hyun Park, Seon-Young Kim, Uh-Hyun Kim

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Dae-Ryoung ParkDepartment of Biochemistry, Chonbuk National University Medical School, Jeonju, Korea; National Creative Research Laboratory for Ca2+ Signaling Network, Chonbuk National University, Jeonju, Korea.
Asif Iqbal ShawlDepartment of Biochemistry, Chonbuk National University Medical School, Jeonju, Korea; National Creative Research Laboratory for Ca2+ Signaling Network, Chonbuk National University, Jeonju, Korea.
Tae-Geun HaDepartment of Biochemistry, Chonbuk National University Medical School, Jeonju, Korea; National Creative Research Laboratory for Ca2+ Signaling Network, Chonbuk National University, Jeonju, Korea.
Kwang-Hyun ParkDepartment of Biochemistry, Chonbuk National University Medical School, Jeonju, Korea; National Creative Research Laboratory for Ca2+ Signaling Network, Chonbuk National University, Jeonju, Korea.
Seon-Young KimDepartment of Biochemistry, Chonbuk National University Medical School, Jeonju, Korea; National Creative Research Laboratory for Ca2+ Signaling Network, Chonbuk National University, Jeonju, Korea.
Uh-Hyun KimDepartment of Biochemistry, Chonbuk National University Medical School, Jeonju, Korea; National Creative Research Laboratory for Ca2+ Signaling Network, Chonbuk National University, Jeonju, Korea; Institute of Cardiovascular Research, Chonbuk National University, Jeonju, Korea.
Jeonbuk National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxothiazolidine carboxylic acid is a prodrug of cysteine that acts as an anti-diabetic agent via insulin secretion and the formation of the Ca2+-mobilizing second messenger, cyclic ADP-ribose (cADPR). Here we show that a hybrid compound, arginine thiazolidine carboxylate (ATC), increases cytoplasmic Ca2+ in pancreatic β-cells, and that the ATC-induced Ca2+ signals result from the sequential formation of two Ca2+-mobilizing second messengers: nicotinic acid adenine dinucleotide phosphate (NAADP) and cADPR. Our data demonstrate that ATC has potent insulin-releasing properties, due to the additive action of its two components; thiazolidine carboxylate (TC) and L-arginine. TC increases glutathione (GSH) levels, resulting in cAMP production, followed by a cascade pathway of NAADP/nitric oxide (NO)/cGMP/cADPR synthesis. L-arginine serves as the substrate for NO synthase (NOS), which results in cADPR synthesis via cGMP formation. Neuronal NOS is specifically activated in pancreatic β-cells upon ATC treatment. These results suggest that ATC is an ideal candidate as an anti-diabetic, capable of modulating the physiological Ca2+ signalling pathway to stimulate insulin secretion.

Indexed as

AnimalsArginineCalciumCalcium SignalingCyclic ADP-RiboseCyclic AMPCyclic GMPGene ExpressionGlutathioneHypoglycemic AgentsInsulinInsulin SecretionIslets of LangerhansMaleMiceMice, Inbred ICRArgininearginine thiazolidinecarboxylateCalciumCyclic ADP-RiboseCyclic AMPCyclic GMPGlutathioneHypoglycemic AgentsInsulinNAADPNADPNitric OxideNitric Oxide Synthase Type INos1 protein, mouseProdrugsThiazolidines

Identifiers

PMID26247205
PMCPMC4527757
OpenAlexW1953461747

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.