ArticlePloS one2015
Inflammatory and Angiogenic Factors at Mid-Pregnancy Are Associated with Spontaneous Preterm Birth in a Cohort of Tanzanian Women.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Is there a maternal blood biomarker that can predict spontaneous preterm birth prior to labour onset? A systematic review.PloS one · 2022Pooled it
- Determinants of preterm birth among mothers who gave birth in East Africa: systematic review and meta-analysis.Italian journal of pediatrics · 2020Pooled it
- Early malaria infection, dysregulation of angiogenesis, metabolism and inflammation across pregnancy, and risk of preterm birth in Malawi: A cohort study.PLoS medicine · 2019Trial
- Systemic inflammation is associated with malaria and preterm birth in women living with HIV on antiretrovirals and co-trimoxazole.Scientific reports · 2019Trial
- The single-cell immune profile throughout gestation and its potential value for identifying women at risk for spontaneous preterm birth.European journal of obstetrics & gynecology and reproductive biology: X · 2025Review
- Article
- Sequential disruptions to inflammatory and angiogenic pathways and risk of spontaneous preterm birth in Malawian women.iScience · 2023Article
- Plasma concentrations of leptin at mid-pregnancy are associated with gestational weight gain among pregnant women in Tanzania: a prospective cohort study.BMC pregnancy and childbirth · 2021Observational
- Spontaneous Preterm Birth: Is Prevention with Aspirin Possible?Geburtshilfe und Frauenheilkunde · 2021Article
- Perspective: L-arginine and L-citrulline Supplementation in Pregnancy: A Potential Strategy to Improve Birth Outcomes in Low-Resource Settings.Advances in nutrition (Bethesda, Md.) · 2019Review
- Alteration in Uterine Protease-Activated Receptor 2 Expression in Preterm Birth Induced Experimentally inReproductive sciences (Thousand Oaks, Calif.) · 2019Article
- The Impact of Infection in Pregnancy on Placental Vascular Development and Adverse Birth Outcomes.Frontiers in microbiology · 2019Review
- Altered angiogenesis as a common mechanism underlying preterm birth, small for gestational age, and stillbirth in women living with HIV.American journal of obstetrics and gynecology · 2017Article
- Severe malaria: what's new on the pathogenesis front?International journal for parasitology · 2017Review
- Metabolite Profile of Cervicovaginal Fluids from Early Pregnancy Is Not Predictive of Spontaneous Preterm Birth.International journal of molecular sciences · 2015Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 3 countries.
Funding
Abstract
research questionPreterm birth (PTB) is the leading cause of perinatal mortality worldwide, with the greatest burden occurring in resource-constrained settings. Based on the hypothesis that altered placental angiogenesis and inflammation early in pregnancy lead to PTB, we examined whether levels of inflammatory and angiogenic mediators, measured early in pregnancy, were predictive of spontaneous PTB (sPTB). STUDY
designPlasma samples were collected from a prospective cohort of primigravid Tanzanian women between 12-27 weeks gestation. A panel of 18 markers was screened on a training cohort of 426 women. Markers associated with sPTB in the training cohort were repeated in a test cohort of 628 women. All markers were measured by ELISA.
findingsIn both the training and test cohorts plasma levels of IL-18BP, sICAM-1, sEndoglin and CHI3L1 were elevated and Leptin was lower at enrollment in women who subsequently experienced sPTB. In multivariate analysis women with plasma levels of CHI3L1, C5a, sICAM-1, AngptL3, sEndgolin, sFlt-1 and IL-18BP in the highest quartile had an increased risk of sPTB compared with those in the lowest quartile. Women with Leptin and Ang2 in the highest quartile had a reduced risk of sPTB compared with women in the lowest quartile. IMPLICATIONS: Levels of angiogenic and inflammatory mediators measured at mid-pregnancy were associated with subsequent sPTB. These findings provide insight into mechanisms underlying sPTB and suggest biomarkers that may have clinical utility in risk-stratifying pregnancies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.