Evidence map›Paper›PMID 26246977›Full record

ArticleExpert opinion on orphan drugs2015

Improvement in vision: a new goal for treatment of hereditary retinal degenerations.

Samuel G Jacobson, Artur V Cideciyan, Gustavo D Aguirre, Alejandro J Roman, Alexander Sumaroka, William W Hauswirth, Krzysztof Palczewski

Open access · bronzeAbstract read
In one paragraph

Article in Expert opinion on orphan drugs, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Clinical Perspective: Treating RPE65-Associated Retinal Dystrophy.Molecular therapy : the journal of the American Society of Gene Therapy · 2021
    Review
  5. Article
  6. Long-Term Structural Outcomes of Late-Stage RPE65 Gene Therapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2020
    Article
  7. Review
  8. Leber Congenital Amaurosis (LCA): Potential for Improvement of Vision.Investigative ophthalmology & visual science · 2019
    Article
  9. Article
  10. Concepts and Strategies in Retinal Gene Therapy.Investigative ophthalmology & visual science · 2017
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Samuel G JacobsonUniversity of Pennsylvania, Scheie Eye Institute, Perelman School of Medicine, Department of Ophthalmology , Philadelphia, PA, USA jacobsos@mail.med.upenn.edu.
Artur V CideciyanUniversity of Pennsylvania, Scheie Eye Institute, Perelman School of Medicine, Department of Ophthalmology , Philadelphia, PA, USA jacobsos@mail.med.upenn.edu.
Gustavo D AguirreUniversity of Pennsylvania, School of Veterinary Medicine, Section of Ophthalmology , Philadelphia, PA, USA.
Alejandro J RomanUniversity of Pennsylvania, Scheie Eye Institute, Perelman School of Medicine, Department of Ophthalmology , Philadelphia, PA, USA jacobsos@mail.med.upenn.edu.
Alexander SumarokaUniversity of Pennsylvania, Scheie Eye Institute, Perelman School of Medicine, Department of Ophthalmology , Philadelphia, PA, USA jacobsos@mail.med.upenn.edu.
William W HauswirthUniversity of Florida, Department of Ophthalmology , Gainesville, FL, USA.
Krzysztof PalczewskiCase Western University, School of Medicine, Cleveland Center for Membrane and Structural Biology, Department of Pharmacology , Cleveland, OH, USA.
University of Pennsylvania · USPenn Presbyterian Medical Center · USUniversity of Florida · USUniversity School · US

Funding

MODELS OF HEREDITY RETINAL DEGENERATIONR01EY006855 · NEI · UNIVERSITY OF PENNSYLVANIA · PI GUSTAVO David AGUIRRE, William A. Beltran · 1992 to 2026
$20.7M
Scientific TransparencyP30EY001583 · NEI · UNIVERSITY OF PENNSYLVANIA · PI Qi N Cui · 1985 to 2026
$19.5M
Translational Research for Retinal Degeneration TherapiesR01EY017549 · NEI · UNIVERSITY OF PENNSYLVANIA · PI BELTRAN, WILLIAM A. · 2007 to 2024
$14.1M
Clinical Trials of Gene Therapy for Leber Congenital AmaurosisU10EY017280 · NEI · UNIVERSITY OF PENNSYLVANIA · PI JACOBSON, SAMUEL GREGORY · 2006 to 2014
$9.8M
NEI NIH HHS P30 EY001583NEI NIH HHS R01 EY006855NEI NIH HHS R01 EY017549NEI NIH HHS U10 EY017280
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

gene therapyLeber congenital amaurosisphotoreceptorsretinaretinal pigment epitheliumretinoid cycle

Identifiers

PMID26246977
PMCPMC4487613
OpenAlexW2148410227

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.