ArticlePeerJ2015
Klebsiella pneumoniae subsp. pneumoniae-bacteriophage combination from the caecal effluent of a healthy woman.
Article in PeerJ, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 52 citations in OpenAlex.
- Characterization and genomic insights into bacteriophages Kpph1 and Kpph9 against hypervirulent carbapenem-resistantVirulence · 2025Article
- Weberviruses are gut-associated phages that infect Klebsiella spp.FEMS microbiology ecology · 2025Article
- Characterization and biocontrol efficacy of lytic phage (KPP-1) that infects multidrug resistant Klebsiella variicola.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Phages against Noncapsulated Klebsiella pneumoniae: Broader Host range, Slower Resistance.Microbiology spectrum · 2023Article
- Characterization of a Lytic Bacteriophage and Demonstration of Its Combined Lytic Effect with a K2 Depolymerase on the HypervirulentMicroorganisms · 2023Article
- AFrontiers in microbiology · 2023Article
- Altered immunity to microbiota, B cell activation and depleted γδ/resident memory T cells in colorectal cancer.Cancer immunology, immunotherapy : CII · 2022Article
- Altered Mucosal Immune-Microbiota Interactions in Familial Adenomatous Polyposis.Clinical and translational gastroenterology · 2022Article
- Urinary Tract Infections Caused byFrontiers in cellular and infection microbiology · 2022Review
- Isolation and Characterization ofPHAGE (New Rochelle, N.Y.) · 2021Article
- Phages from Ganges River curtail in vitro biofilms and planktonic growth of drug resistant Klebsiella pneumoniae in a zebrafish infection model.AMB Express · 2021Article
- Characterization of four virulent Klebsiella pneumoniae bacteriophages, and evaluation of their potential use in complex phage preparation.Virology journal · 2021Article
- Characteristics of a Bacteriophage, vB_Kox_ZX8, Isolated From ClinicalFrontiers in microbiology · 2021Article
- Characterization of extended-spectrum-β-lactamase producing Klebsiella pneumoniae phage KP1801 and evaluation of therapeutic efficacy in vitro and in vivo.Scientific reports · 2020Article
- Bacteroides thetaiotaomicron-derived outer membrane vesicles promote regulatory dendritic cell responses in health but not in inflammatory bowel disease.Microbiome · 2020Article
- Deficient Resident Memory T Cell and CD8 T Cell Response to Commensals in Inflammatory Bowel Disease.Journal of Crohn's & colitis · 2020Article
- Bacteriophages ofJournal of medical microbiology · 2020Review
- Biological properties and genomics analysis of vB_KpnS_GH-K3, a Klebsiella phage with a putative depolymerase-like protein.Virus genes · 2019Article
- Characterization of a Lytic Bacteriophage as an Antimicrobial Agent for Biocontrol of Shiga Toxin-ProducingAntibiotics (Basel, Switzerland) · 2019Article
- Diversity and Function of Phage Encoded Depolymerases.Frontiers in microbiology · 2019Review
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A sample of caecal effluent was obtained from a female patient who had undergone a routine colonoscopic examination. Bacteria were isolated anaerobically from the sample, and screened against the remaining filtered caecal effluent in an attempt to isolate bacteriophages (phages). A lytic phage, named KLPN1, was isolated on a strain identified as Klebsiella pneumoniae subsp. pneumoniae (capsular type K2, rmpA (+)). This Siphoviridae phage presents a rosette-like tail tip and exhibits depolymerase activity, as demonstrated by the formation of plaque-surrounding haloes that increased in size over the course of incubation. When screened against a panel of clinical isolates of K. pneumoniae subsp. pneumoniae, phage KLPN1 was shown to infect and lyse capsular type K2 strains, though it did not exhibit depolymerase activity on such hosts. The genome of KLPN1 was determined to be 49,037 bp (50.53 %GC) in length, encompassing 73 predicted ORFs, of which 23 represented genes associated with structure, host recognition, packaging, DNA replication and cell lysis. On the basis of sequence analyses, phages KLPN1 (GenBank: KR262148) and 1513 (a member of the family Siphoviridae, GenBank: KP658157) were found to be two new members of the genus "Kp36likevirus."
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.