Trial reportJournal of obesity2015
Sustained Weight Loss with Vagal Nerve Blockade but Not with Sham: 18-Month Results of the ReCharge Trial.
Trial report in Journal of obesity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed.
- 20-kHz alternating current stimulation: effects on motor and somatosensory thresholds.Journal of neuroengineering and rehabilitation · 2020Trial
- Laparoscopic vagal nerve blocking device explantation: case series and report of operative technique.Surgical endoscopy · 2019Trial
- Implanted Closed-Loop Gastric Electrical Stimulation (CLGES) System with Sensor-Based Feedback Safely Limits Weight Regain at 24 Months.Obesity surgery · 2018Trial
- Two-Year Outcomes of Vagal Nerve Blocking (vBloc) for the Treatment of Obesity in the ReCharge Trial.Obesity surgery · 2017Trial
- Closed-loop gastric electrical stimulation versus laparoscopic adjustable gastric band for the treatment of obesity: a randomized 12-month multicenter study.International journal of obesity (2005) · 2016Trial
- Effect of Vagal Nerve Blockade on Moderate Obesity with an Obesity-Related Comorbid Condition: the ReCharge Study.Obesity surgery · 2016Trial
- From Approval to Evidence: Device Regulation, Long-Term Outcomes, and Conflicts of Interest in Metabolic Bariatric Surgery.Obesity surgery · 2026Review
- Application of kilohertz-frequency block to mitigate off-target motor effects of vagus nerve stimulation in swine.Nature communications · 2025Article
- Mechanisms of metabolic surgery effectiveness in obesity and type 2 diabetes: a puzzle with some known pieces.International journal of obesity (2005) · 2025Review
- Recent advances in targeting obesity, with a focus on TGF-β signaling and vagus nerve innervation.Bioelectronic medicine · 2025Review
- Mechanism and Applications of Vagus Nerve Stimulation.Current issues in molecular biology · 2025Review
- Critical Correlation Between Obesity and Cardiovascular Diseases and Recent Advancements in Obesity.Cureus · 2024Review
- Obesity management for cardiovascular disease prevention.Obesity pillars · 2023Review
- Electroceuticals for Neurogastroenterology and Motility Disorders.Current gastroenterology reports · 2023Review
- Neuromodulation for functional upper gastrointestinal diseases.Gut microbiota and integrative wellness · 2023Article
- Clinical perspectives on vagus nerve stimulation: present and future.Clinical science (London, England : 1979) · 2022Review
- Reduced Liver-Specific PGC1a Increases Susceptibility for Short-Term Diet-Induced Weight Gain in Male Mice.Nutrients · 2021Article
- Both high fat and high carbohydrate diets impair vagus nerve signaling of satiety.Scientific reports · 2021Article
- Characterization of a cell bridge variant connecting the nodose and superior cervical ganglia in the mouse: Prevalence, anatomical features, and practical implications.The Journal of comparative neurology · 2021Article
- The Phantom Satiation Hypothesis of Bariatric Surgery.Frontiers in neuroscience · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesVagal block therapy (vBloc) is effective for moderate to severe obesity at one year. SUBJECTS/
methodsThe ReCharge trial is a double-blind, randomized controlled clinical trial of 239 participants with body mass index (BMI) of 40 to 45 kg/m or 35 to 40 kg/m with one or more obesity-related conditions. Interventions were implantation of either vBloc or Sham devices and weight management counseling. Mixed models assessed percent excess weight loss (%EWL) and total weight loss (%TWL) in intent-to-treat analyses. At 18 months, 142 (88%) vBloc and 64 (83%) Sham patients remained enrolled in the study.
results18-month weight loss was 23% EWL (8.8% TWL) for vBloc and 10% EWL (3.8% TWL) for Sham (P < 0.0001). vBloc patients largely maintained 12-month weight loss of 26% EWL (9.7% TWL). Sham regained over 40% of the 17% EWL (6.4% TWL) by 18 months. Most weight regain preceded unblinding. Common adverse events of vBloc through 18 months were heartburn/dyspepsia and abdominal pain; 98% of events were reported as mild or moderate and 79% had resolved.
conclusionsWeight loss with vBloc was sustained through 18 months, while Sham regained weight between 12 and 18 months. vBloc is effective with a low rate of serious complications.
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