ReviewAutoimmune diseases2015
Understanding and Managing Pregnancy in Patients with Lupus.
Review in Autoimmune diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 101 citations in OpenAlex.
- Relation of Chlamydia trachomatis infections to ectopic pregnancy: A meta-analysis and systematic review.Medicine · 2020Pooled it
- Analysis of the Longitudinal Behavior of Serum Levels of Soluble Flt1 and Placental Growth Factor in Pregnant Patients With Systemic Lupus Erythematosus.Arthritis care & research · 2025Article
- Article
- Pregnancy outcomes and risk factors for thrombocytopenia in pregnant patients with systemic lupus erythematosus.BMC pregnancy and childbirth · 2025Article
- Postpartum uterine atony complicating labor in a patient with systemic lupus erythematosus: A case report.SAGE open medical case reports · 2025Article
- Exploring the transcriptomic landscape of moyamoya disease and systemic lupus erythematosus: insights into crosstalk genes and immune relationships.Frontiers in immunology · 2024Article
- Maternal Near Miss in Patients with Systemic Lupus Erythematosus.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2023Article
- The association of lupus nephritis with adverse pregnancy outcomes among women with lupus in North America.Lupus · 2022Article
- Preparing for Pregnancy in Women with Systemic Lupus Erythematosus-A Multidisciplinary Approach.Medicina (Kaunas, Lithuania) · 2022Review
- Diffuse myometrium thinning and placenta accreta spectrum in a patient with systemic lupus erythematosus (SLE): a case report and review of the literature.BMC pregnancy and childbirth · 2022Review
- Clinical study of factors associated with pregnancy outcomes in pregnant women with systemic lupus erythematosus in the southern China.Archives of rheumatology · 2022Article
- Placental Ischemia Says "NO" to Proper NOS-Mediated Control of Vascular Tone and Blood Pressure in Preeclampsia.International journal of molecular sciences · 2021Review
- Maternal genetics influences fetal neurodevelopment and postnatal autism spectrum disorder-like phenotype by modulating in-utero immunosuppression.Translational psychiatry · 2021Article
- Pregnancy Outcomes in Systemic Lupus Erythematosus Women: A single tertiary centre experience.Sultan Qaboos University medical journal · 2021Article
- Favorable Pregnancy Outcomes in Women With Well-Controlled Pulmonary Arterial Hypertension.Frontiers in medicine · 2021Article
- Lupus-Induced Vasculitis and Multiple Organ Dysfunction Syndrome as the First Presentation of Systemic Lupus Erythematosus (SLE) in Pregnancy.The American journal of case reports · 2020Article
- Risk of adverse obstetric outcomes in Japanese women with systemic lupus erythematosus: The Japan Environment and Children's Study.PloS one · 2020Article
- Detection of epitopes in systemic lupus erythematosus using peptide microarray.Molecular medicine reports · 2018Article
- A Critical Review on Obstetric Follow-up of Women Affected by Systemic Lupus Erythematosus.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2018Review
- A Population-based Study of Perinatal Infection Risk in Women with and without Systemic Lupus Erythematosus and their Infants.Paediatric and perinatal epidemiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Systemic lupus erythematosus (SLE) is a chronic, multisystemic autoimmune disease that occurs predominantly in women of fertile age. The association of SLE and pregnancy, mainly with active disease and especially with nephritis, has poorer pregnancy outcomes, with increased frequency of preeclampsia, fetal loss, prematurity, growth restriction, and newborns small for gestational age. Therefore, SLE pregnancies are considered high risk condition, should be monitored frequently during pregnancy and delivery should occur in a controlled setting. Pregnancy induces dramatic immune and neuroendocrine changes in the maternal body in order to protect the fetus from immunologic attack and these modifications can be affected by SLE. The risk of flares depends on the level of maternal disease activity in the 6-12 months before conception and is higher in women with repeated flares before conception, in those who discontinue useful medications and in women with active glomerulonephritis at conception. It is a challenge to differentiate lupus nephritis from preeclampsia and, in this context, the angiogenic and antiangiogenic cytokines are promising. Prenatal care of pregnant patients with SLE requires close collaboration between rheumatologist and obstetrician. Planning pregnancy is essential to increase the probability of successful pregnancies.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.