Evidence map›Paper›PMID 26246898›Full record

ArticleSAGE open medicine2014

Examination of the potential association of stress with morbidity and mortality outcomes in patient with heart failure.

Abdullah S Alhurani, Rebecca Dekker, Elizabeth Tovar, Alison Bailey, Terry A Lennie, David C Randall, Debra K Moser

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in SAGE open medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Abdullah S AlhuraniCollege of Nursing, University of Kentucky, Lexington, KY, USA ; The University of Jordan, Amman, Jordan.
Rebecca DekkerCollege of Nursing, University of Kentucky, Lexington, KY, USA.
Elizabeth TovarCollege of Nursing, University of Kentucky, Lexington, KY, USA.
Alison BaileyCollege of Nursing, University of Kentucky, Lexington, KY, USA.
Terry A LennieCollege of Nursing, University of Kentucky, Lexington, KY, USA.
David C RandallCollege of Nursing, University of Kentucky, Lexington, KY, USA.
Debra K MoserCollege of Nursing, University of Kentucky, Lexington, KY, USA.
University of Kentucky · USUniversity of Jordan · JO

Funding

Biobehavioral Intervention in Heart FailureR01NR008567 · NINR · UNIVERSITY OF KENTUCKY · PI MOSER, DEBRA KAY · 2004 to 2008
$1.5M
BMI, Nutrition, Inflammation and Heart Failure OutcomesR01NR009280 · NINR · UNIVERSITY OF KENTUCKY · PI LENNIE, TERRY A · 2005 to 2007
$1.5M
Self-Management Pilot/Feasibility and Biobehavioral Outcomes CoreP20NR010679 · NINR · UNIVERSITY OF KENTUCKY · PI HALL, LYNNE ANDERSON · 2007 to 2011
$1.2M
Cognitive Therapy for Depressive Symptoms in Hospitalized Patients with Heart FaiK23NR013480 · NINR · UNIVERSITY OF KENTUCKY · PI DEKKER, REBECCA · 2012 to 2014
$356k
NINR NIH HHS K23 NR013480NINR NIH HHS P20 NR010679NINR NIH HHS R01 NR008567NINR NIH HHS R01 NR009280
6 · The paper itself

Abstract

objectivesThe high mortality and morbidity rates associated with heart failure are still not well explained. A few psychosocial factors have been studied and explain some of this risk, but other factors, like stress, remain largely unexplored in heart failure. This study aimed to (1) examine the association of stress with 6-month cardiac event-free survival, (2) examine the relationship of stress with salivary cortisol, and (3) examine the association of salivary cortisol level with 6-month cardiac event-free survival.

methodA total of 81 heart failure patients participated. Stress was measured using the brief Perceived Stress Scale. Cortisol was measured from unstimulated whole expectorated saliva. Cox regression analyses were used to determine whether stress predicted event-free survival, and if salivary cortisol predicted event-free survival. Linear and multiple regressions were used to determine the association of stress with salivary cortisol.

resultsStress was not a significant predictor of event-free survival in heart failure (heart rate = 1.06; 95% confidence interval = 0.95-1.81; p = 0.32). Salivary cortisol was a significant predictor of event-free survival in the unadjusted model (heart rate = 2.30; 95% confidence interval = 0.99-5.927; p = 0.05), but not in the adjusted model. Stress (β 1.06; 95% confidence interval = 0.95-1.18; p = 0.32) was not a significant predictor of salivary cortisol level.

conclusionStress is a complex phenomenon, and our measure of stress may not have captured it well. Alternatively, the physical stressors acting in heart failure produce levels of neurohormonal activation that mask the effects of psychosocial stressors or an indirect association of stress with outcomes that is mediated through another construct. Future studies are needed to investigate stress in patients with heart failure to provide definitive answers.

Indexed as

cortisolevent-free survivalhealth outcomesheart failureStress

Identifiers

PMID26246898
PMCPMC4523379
OpenAlexW2102457453

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.