Evidence map›Paper›PMID 26246865›Full record

ArticleBayesian analysis2013

Nonparametric Bayesian Bi-Clustering for Next Generation Sequencing Count Data.

Yanxun Xu, Juhee Lee, Yuan Yuan, Riten Mitra, Shoudan Liang, Peter Müller, Yuan Ji

Open access · diamondAbstract read
In one paragraph

Article in Bayesian analysis, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. A Bayesian feature allocation model for identifying cell subpopulations using CyTOF data.Journal of the Royal Statistical Society. Series C, Applied statistics · 2023
    Article
  5. Article
  6. Article
  7. Bayesian Double Feature Allocation for Phenotyping with Electronic Health Records.Journal of the American Statistical Association · 2020
    Article
  8. A nonparametric Bayesian basket trial design.Biometrical journal. Biometrische Zeitschrift · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Yanxun XuDepartment of Statistics, Rice University, Houston, TX, U.S.A. ; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, U.S.A.
Juhee LeeDepartment of Statistics, The Ohio State University, Columbus, Ohio, U.S.A.
Yuan YuanGraduate Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, TX, U.S.A.
Riten MitraDepartment of Mathematics, University of Texas Austin, Austin, TX, U.S.A.
Shoudan LiangDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, U.S.A.
Peter MüllerDepartment of Mathematics, University of Texas Austin, Austin, TX, U.S.A.
Yuan JiNorthShore University HealthSystem, Chicago, IL, U.S.A.
The University of Texas at Austin · USBaylor College of Medicine · USNorthShore University HealthSystem · USThe Ohio State University · USThe University of Texas MD Anderson Cancer Center · US

Funding

Bayesian models for cancer prognosis by integrating diverse types of dataR01CA132897 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI JI, YUAN, MUELLER, PETER · 2008 to 2019
$2.1M
Genome-wide Identification of Minor Histocompatibility AntigensK25CA123344 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LIANG, SHOUDAN · 2008 to 2012
$734k
NCI NIH HHS K25 CA123344NCI NIH HHS R01 CA132897
6 · The paper itself

Abstract

Histone modifications (HMs) play important roles in transcription through post-translational modifications. Combinations of HMs, known as chromatin signatures, encode specific messages for gene regulation. We therefore expect that inference on possible clustering of HMs and an annotation of genomic locations on the basis of such clustering can contribute new insights about the functions of regulatory elements and their relationships to combinations of HMs. We propose a nonparametric Bayesian local clustering Poisson model (NoB-LCP) to facilitate posterior inference on two-dimensional clustering of HMs and genomic locations. The NoB-LCP clusters HMs into HM sets and lets each HM set define its own clustering of genomic locations. Furthermore, it probabilistically excludes HMs and genomic locations that are irrelevant to clustering. By doing so, the proposed model effectively identifies important sets of HMs and groups regulatory elements with similar functionality based on HM patterns.

Indexed as

Bi-ClusteringChIP-SeqHistone modificationsMarkov chain Monte CarloNonparametric Bayes

Identifiers

PMID26246865
PMCPMC4523245
OpenAlexW2034724814

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.