ArticleDialogues in clinical neuroscience2015
Challenges in the diagnosis and treatment of depression in autism spectrum disorders across the lifespan.
Article in Dialogues in clinical neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 110 citations in OpenAlex.
- Emotion Reactivity and Regulation in Autistic Adults: A Systematic Review Across RDoC Units of Analysis.Psychophysiology · 2025Pooled it
- Prevalence of Depressive Disorders in Individuals with Autism Spectrum Disorder: a Meta-Analysis.Journal of abnormal child psychology · 2019Pooled it
- Gray Matter Volume Correlates of Co-Occurring Depression in Autism Spectrum Disorder.Journal of autism and developmental disorders · 2026Article
- Depression and anxiety are increased in autism and ADHD: Evidence from a young adult community-based sample.JCPP advances · 2025Article
- Stability and Validity of Self-Reported Depression and Anxiety in Autistic Youth.Journal of autism and developmental disorders · 2025Article
- Psychometric Properties of Measuring Tools for Depression in Autistic Youths: A Systematic Review.Journal of autism and developmental disorders · 2025Article
- Autism Spectrum Disorder and Epilepsy: Pathogenetic Mechanisms and Therapeutic Implications.Journal of clinical medicine · 2025Review
- Symptoms of depression in autistic children and adolescents.Frontiers in psychiatry · 2025Article
- Altered Rhythmicity, Depressive Ruminative Thinking and Suicidal Ideation as Possible Correlates of an Unrecognized Autism Spectrum in Patients with Borderline Personality Disorder.Brain sciences · 2024Article
- Stronger Associations Between Sleep and Mental Health in Adults with Autism: A UK Biobank Study.Journal of autism and developmental disorders · 2023Article
- Review
- Connective differences between patients with depression with and without ASD: A case-control study.PloS one · 2023Article
- Characterization of Adult Patients with Autism Spectrum Disorder that Use Patient Portal.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2023Article
- Ketamine Self-Medication in a Patient with Autism Spectrum Disorder and Comorbid Therapy-Resistant Depression.Psychiatry and clinical psychopharmacology · 2022Article
- Roozbeh adult autism spectrum disorder clinic: lessons learned from first 34 cases.International journal of developmental disabilities · 2022Article
- Vagus Nerve Stimulation as a Treatment for Fear and Anxiety in Individuals with Autism Spectrum Disorder.Journal of psychiatry and brain science · 2022Article
- Diagnostic- and sex-based differences in depression symptoms in autistic and neurotypical early adolescents.Autism : the international journal of research and practice · 2022Article
- Looking Back at the Next 40 Years of ASD Neuroscience Research.Journal of autism and developmental disorders · 2021Review
- Is a Negative Attentional Bias in Individuals with Autism Spectrum Disorder Explained by Comorbid Depression? An Eye-Tracking Study.Journal of autism and developmental disorders · 2021Article
- Drug development for Autism Spectrum Disorder (ASD): Progress, challenges, and future directions.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diagnosis and treatment of comorbid neuropsychiatric illness is often a secondary focus of treatment in individuals with autism spectrum disorder (ASD), given that substantial impairment may be caused by core symptoms of ASD itself. However, psychiatric comorbidities, including depressive disorders, are common and frequently result in additional functional impairment, treatment costs, and burden on caregivers. Clinicians may struggle to appropriately diagnose depression in ASD due to communication deficits, atypical presentation of depression in ASD, and lack of standardized diagnostic tools. Specific risk and resilience factors for depression in ASD across the lifespan, including level of functioning, age, family history, and coping style, have been suggested, but require further study. Treatment with medications or psychotherapy may be beneficial, though more research is required to establish guidelines for management of symptoms. This review will describe typical presentations of depression in individuals with ASD, review current information on the prevalence, assessment, and treatment of comorbid depression in individuals with ASD, and identify important research gaps.
Indexed as
Identifiers
26246795PMC4518704W1420430496What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.