ArticlePharmacognosy magazine
Flavonoids isolated from Lespedeza cuneata G. Don and their inhibitory effects on nitric oxide production in lipopolysaccharide-stimulated BV-2 microglia cells.
Article in Pharmacognosy magazine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 28 citations in OpenAlex.
- Molecular Networking and Mass2Motif Analysis Prioritise Glycosylated Triterpenoid-Related Chemical Space in the Cytotoxic Fractions of EdibleFoods (Basel, Switzerland) · 2026Article
- Polyphenols from the aerial parts of Lespedeza cuneata and their inhibitory effects on PTP1B and α-glucosidase: insights from in vitro and in Silico analyses.Journal of natural medicines · 2026Article
- Comparative Analysis ofMolecules (Basel, Switzerland) · 2025Review
- A Single-Center, Randomized, Double-Blind, and Placebo-Controlled Comparative Human Study to Verify the Functionality and Safety of the Lespedeza cuneata G. Don Extract for the Improvement of Aging Male Syndrome.Urology research & practice · 2023Article
- 1-Methoxylespeflorin G11 Protects HT22 Cells from Glutamate-Induced Cell Death through Inhibition of ROS Production and Apoptosis.Journal of microbiology and biotechnology · 2021Article
- Aviculin Isolated fromMolecules (Basel, Switzerland) · 2020Article
- Three new compounds with nitric oxide inhibitory activity fromBMC chemistry · 2019Article
- Lignan Glycosides and Flavonoid Glycosides from the Aerial Portion ofMolecules (Basel, Switzerland) · 2018Article
- Antiwrinkle and antimelanogenesis activity of the ethanol extracts ofFood science & nutrition · 2018Article
- Juglanin suppresses fibrosis and inflammation response caused by LPS in acute lung injury.International journal of molecular medicine · 2018Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLespedeza cuneata (Dum. Cours.) G. Don, a perennial legume native to Eastern Asia, has been used therapeutically in traditional Asian medicine to protect the function of liver, kidneys and lungs. However, its effect on inflammatory nitric oxide (NO) production and the active constituents have not yet been explored.
objectiveIn this study, we investigated the phytochemical constituents of L. cuneata and evaluated their effect on NO production using lipopolysaccharide (LPS)-stimulated BV2 cells. MATERIALS AND
methodsThe 80% methanol extract of the aerial part of L. cuneata were used for the isolation of flavonoids. The isolated compounds were elucidated by various spectroscopic methods including nuclear magnetic resonance and mass spectrometry spectrometry. To evaluate the effect on inflammatory NO production, LPS-stimulated murine microglia BV-2 cells were used as a screening system.
resultsNine flavonoids were isolated from the aerial parts of L. cuneata. Among the isolated flavonoids, compounds 4, 5, 7 and 9 are reported from the genus Lespedeza for the first time. Moreover, compounds 1 and 6 showed significant inhibitory effects on NO production in LPS-stimulated BV2 cells without cell toxicity.
conclusionIn this study, nine flavonoids were isolated from L. cuneata. Among the compounds, only 1 and 6, which have free hydroxyl groups at both C3 and C7 showed significant inhibitory activity on NO production in LPS-stimulated BV2 cells. These results suggested L. cuneata and its flavonoid constituents as possible candidate for the treatment of various inflammatory diseases.
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