ArticlePharmacognosy magazine
Anti-aging effect of polysaccharide from Bletilla striata on nematode Caenorhabditis elegans.
Article in Pharmacognosy magazine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 67 citations in OpenAlex.
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- Study on Process Optimization and Antioxidant Activity of Polysaccharide fromMolecules (Basel, Switzerland) · 2023Article
- The Role and Mechanism of Polysaccharides in Anti-Aging.Nutrients · 2022Review
- Purification, characterization, and determination of biological activities of water-soluble polysaccharides from Mahonia bealei.Scientific reports · 2022Article
- Polysaccharide-Based Transdermal Drug Delivery.Pharmaceuticals (Basel, Switzerland) · 2022Review
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- Discovery and identification of potential anti-melanogenic active constituents of Bletilla striata by zebrafish model and molecular docking.BMC complementary medicine and therapies · 2022Article
- Characterization and Evaluation of the Pro-Coagulant and Immunomodulatory Activities of Polysaccharides fromACS omega · 2021Article
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- A Review of Isolation, Chemical Properties, and Bioactivities of Polysaccharides fromBioMed research international · 2020Review
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- Preliminary characterization of the structure and immunostimulatory and anti-aging properties of the polysaccharide fraction ofRSC advances · 2018Article
- Current Perspective in the Discovery of Anti-aging Agents from Natural Products.Natural products and bioprospecting · 2017Review
- Longevity effect of a polysaccharide from Chlorophytum borivilianum on Caenorhabditis elegans and Saccharomyces cerevisiae.PloS one · 2017Article
- Screening lifespan-extending drugs in Caenorhabditis elegans via label propagation on drug-protein networks.BMC systems biology · 2016Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPolysaccharide isolated from Bletilla striata, a well-known traditional Chinese medicine (Bletilla striata polysaccharide [BSP]) has been found to play important roles in endothelial cells proliferation, inducible nitric oxide stimulation, wound healing acceleration and other processes. Recent studies found that B. striata has anti-oxidative properties, however, potential anti-aging effects of BSP in whole organisms has not been characterized.
objectiveTo investigate whether BSP has anti-aging effects on Caenorhabditis elegans. MATERIALS AND
methodsAfter treatment with BSP, the lifespan, locomotion ability, and stress resistance of C. elegans was determined. To provide insight into the underlying mechanism for the anti-aging effect of BSP, we measured its effect on bacterial growth, brood size of C. elegans, and the insulin/insulin-like growth factor (IGF) signaling pathway.
resultsAfter BSP treatment, the lifespan of C. elegans was extended, and its locomotion ability and stress resistance were increased. BSP was found to have no effect on bacterial growth or on reproduction of C. elegans, However, mRNA levels of age-1 and hcf-1 were reduced after BSP treatment. Additionally, we observed that BSP did not extend the lifespan of daf-16 mutant animals.
conclusionBSP produces an anti-aging effect on C. elegans through the insulin/IGF signaling pathway and holds promise for future development as a functional food.
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