Trial reportThe Canadian veterinary journal = La revue veterinaire canadienne2015
Short- and long-term effects of platelet-rich plasma upon healthy equine joints: Clinical and laboratory aspects.
Trial report in The Canadian veterinary journal = La revue veterinaire canadienne, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Changes in biomarkers in equine synovial fluid two weeks after intra-articular hyaluronan treatment: a randomised double-blind clinical trial.BMC veterinary research · 2018Trial
- Investigation into the Short-Term Effects of Intra-Articular Allogenic PRP in the Equine LPS Model of Joint Inflammation: A Randomised Control Trial.Animals : an open access journal from MDPI · 2026Article
- Platelet-Rich Plasma in Equine Osteoarthritis: A Systematic Review of Clinical and Experimental Evidence.Animals : an open access journal from MDPI · 2025Review
- Safety study of leucoreduced allogeneic pooled freeze-dried platelet-rich plasma in healthy equine joints.Frontiers in veterinary science · 2025Article
- Effects of intra-articular administration of hyaluronic acid or platelet-rich plasma as a complementary treatment to arthroscopy in horses with osteochondritis dissecans.Veterinary and animal science · 2024Article
- Enhancing Pain Relief in Temporomandibular Joint Arthrocentesis: Platelet-Rich Plasma and Hyaluronic Acid Synergy.Cureus · 2023Review
- Current use of biologic therapies for musculoskeletal disease: A survey of board-certified equine specialists.Veterinary surgery : VS · 2022Article
- A safety evaluation of allogeneic freeze-dried platelet-rich plasma or conditioned serum compared to autologous frozen products equivalents in equine healthy joints.BMC veterinary research · 2022Article
- Regenerative Medicine for Equine Musculoskeletal Diseases.Animals : an open access journal from MDPI · 2021Review
- Cultured Horse Articular Chondrocytes in 3D-Printed Chitosan Scaffold With Hyaluronic Acid and Platelet Lysate.Frontiers in veterinary science · 2021Article
- A Critical Overview of the Use of Platelet-Rich Plasma in Equine Medicine Over the Last Decade.Frontiers in veterinary science · 2021Review
- Hyaluronic acid has chondroprotective and joint-preserving effects on LPS-induced synovitis in horses.Journal of veterinary science · 2019Article
- Equine Allogeneic Chondrogenic Induced Mesenchymal Stem Cells Are an Effective Treatment for Degenerative Joint Disease in Horses.Stem cells and development · 2019Article
- Effects of medical ozone upon healthy equine joints: Clinical and laboratorial aspects.PloS one · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to verify whether transient inflammatory reactions incited by the administration of intra-articular platelet-rich plasma (PRP) affected joint components through short- and long-term in vivo evaluation of inflammatory biomarkers and extracellular matrix degradation products in synovial fluid. The effects of PRP were analyzed in a short phase protocol (SPP) and in a prolonged phase protocol (PPP), using saline-injected joints as controls. In the SPP, higher white blood cell counts and prostaglandin E2 and total protein concentrations were observed in the synovial fluid of PRP-treated joints (P < 0.05). There were no differences between the interleukin-1β, interleukin-1 receptor antagonist protein, tumor necrosis factor-α, chondroitin sulfate, or hyaluronic acid concentrations between PRP and saline injected joints. In the PPP, there were no differences in evaluated parameters between groups. PRP injection elicits a mild and self-limiting inflammatory response shortly after administration, without long-term deleterious effects on joint homeostasis.
Indexed as
Identifiers
26246629PMC4502851What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.