Evidence map›Paper›PMID 26246571›Full record

ArticleJournal of virology2015

Soluble Envelope Glycoprotein Trimers from a CD4-Independent HIV-1 Elicit Antibody-Dependent Cellular Cytotoxicity-Mediating Antibodies in Guinea Pigs.

Marta K Murray, Victor A Teran, Jean-Philippe Chapleau, Baomin Wang, Su Hyon Kim, Celia C LaBranche, Jonathan Richard, David C Montefiori, Andrés Finzi, Wen Yuan

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Marta K MurrayDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA.
Victor A TeranDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA.
Jean-Philippe ChapleauCentre de Recherche du CHUM and Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, Quebec, Canada.
Baomin WangDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA.
Su Hyon KimDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA.
Celia C LaBrancheMontreal, Quebec, Canada; Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Jonathan RichardCentre de Recherche du CHUM and Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, Quebec, Canada.
David C MontefioriMontreal, Quebec, Canada; Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Andrés FinziCentre de Recherche du CHUM and Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, Quebec, Canada Department of Microbiology and Immunology, McGill University wy5e@virginia.edu andres.finzi@umontreal.ca.
Wen YuanDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA Myles H. Thaler Center for AIDS and Human Retrovirus Research, University of Virginia Health System, Charlottesville, Virginia, USA wy5e@virginia.edu andres.finzi@umontreal.ca.
University of Virginia Health System · USCentre Hospitalier de l’Université de Montréal · CADuke Medical Center · US

Funding

Functional HIV Envelope Trimer as a Prophylactic HIV/AIDS Vaccine CandidateR33AI081616 · NIAID · UNIVERSITY OF VIRGINIA · PI YUAN, WEN · 2011 to 2013
$1.3M
An HIV Vaccine Candidate Targeting the Coreceptor Binding SiteR21AI087502 · NIAID · UNIVERSITY OF VIRGINIA · PI YUAN, WEN · 2010 to 2011
$421k
Functional HIV Envelope Trimer as a Prophylactic HIV/AIDS Vaccine CandidateR21AI081616 · NIAID · UNIVERSITY OF VIRGINIA · PI YUAN, WEN · 2009 to 2010
$410k
Canadian Institutes of Health Research 119334Canadian Institutes of Health Research 134117Canadian Institutes of Health Research 135349NIAID NIH HHS AI081616NIAID NIH HHS AI087502NIAID NIH HHS R21 AI081616NIAID NIH HHS R21 AI087502NIAID NIH HHS R33 AI081616PHS HHS HHSN27201100016C
6 · The paper itself

Abstract

CD4-independent HIV-1 variants can infect coreceptor-expressing cells lacking CD4. The envelope (Env) glycoproteins on these HIV-1 variants expose a coreceptor binding site that overlaps some CD4-induced (CD4i) epitopes. Reports have demonstrated that CD4i antibodies mediate antibody-dependent cellular cytotoxicity (ADCC). Here we investigated the immunogenicity of soluble Env trimers (sgp140) from a CD4-independent HIV-1 in guinea pigs and found that the sgp140 elicited ADCC-mediating antibodies. Therefore, these sgp140 might be useful in vaccine regimens aimed at eliciting ADCC responses.

Indexed as

AnimalsAntibody-Dependent Cell CytotoxicityBinding SitesCD4 Antigensenv Gene Products, Human Immunodeficiency VirusEpitopesGene ExpressionGuinea PigsHIV-1HIV AntibodiesHIV InfectionsHumansImmunizationProtein BindingProtein MultimerizationSolubilityCD4 Antigensenv Gene Products, Human Immunodeficiency VirusEpitopesHIV Antibodies

Identifiers

PMID26246571
PMCPMC4580154
OpenAlexW1911033600

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.