ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2015
Vascular versus tubular renin: role in kidney development.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 42 citations in OpenAlex.
- Renin cells orchestrate a neuro-endocrine microenvironment of the kidney arterial tree in health and disease.JCI insight · 2026Article
- Review
- Krüppel-like factor 2 regulates renin expression in mature juxtaglomerular cells.American journal of physiology. Renal physiology · 2026Article
- Article
- The kidney stroma in development and disease.Nature reviews. Nephrology · 2025Review
- Calcium Oscillations Within Juxtaglomerular Cell Clusters Control Renin Release.Circulation research · 2025Article
- Bright Cells, and Inefficient Enzymatic Activity in a Renin Hypomorph Mouse.bioRxiv : the preprint server for biology · 2025Article
- Piezo channels in JG cells do not regulate renin expression or renin release to the circulation.Clinical science (London, England : 1979) · 2024Article
- A genetically inducible endothelial niche enables vascularization of human kidney organoids with multilineage maturation and emergence of renin expressing cells.Kidney international · 2024Article
- A Possible Link between Cell Plasticity and Renin Expression in the Collecting Duct: A Narrative Review.International journal of molecular sciences · 2024Review
- An efficient inducible model for the control of gene expression in renin cells.American journal of physiology. Renal physiology · 2024Article
- Netrin 1 directs vascular patterning and maturity in the developing kidney.Development (Cambridge, England) · 2023Article
- Cells of the renin lineage promote kidney regeneration post-release of ureteral obstruction in neonatal mice.Acta physiologica (Oxford, England) · 2023Article
- Renal cystic disease in tuberous sclerosis complex.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- Patterns of differentiation of renin lineage cells during nephrogenesis.American journal of physiology. Renal physiology · 2021Article
- Activation of the renal GLP-1R leads to expression ofEndocrinology, diabetes & metabolism · 2021Article
- Renin Cells, the Kidney, and Hypertension.Circulation research · 2021Review
- Renin-angiotensin system in mammalian kidney development.Pediatric nephrology (Berlin, Germany) · 2021Review
- Deciphering the Identity of Renin Cells in Health and Disease.Trends in molecular medicine · 2021Review
- Genetic renal disease classification by hormonal axes.Pediatric nephrology (Berlin, Germany) · 2020Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Renin, the key regulated enzyme of the renin-angiotensin system regulates blood pressure, fluid-electrolyte homeostasis, and renal morphogenesis. Whole body deletion of the renin gene results in severe morphological and functional derangements, including thickening of renal arterioles, hydronephrosis, and inability to concentrate the urine. Because renin is found in vascular and tubular cells, it has been impossible to discern the relative contribution of tubular versus vascular renin to such a complex phenotype. Therefore, we deleted renin independently in the vascular and tubular compartments by crossing Ren1(c fl/fl) mice to Foxd1-cre and Hoxb7-cre mice, respectively. Deletion of renin in the vasculature resulted in neonatal mortality that could be rescued with daily injections of saline. The kidneys of surviving mice showed the absence of renin, hypertrophic arteries, hydronephrosis, and negligible levels of plasma renin. In contrast, lack of renin in the collecting ducts did not affect kidney morphology, intra-renal renin, or circulating renin in basal conditions or in response to a homeostatic stress, such as sodium depletion. We conclude that renin generated in the renal vasculature is fundamental for the development and integrity of the kidney, whereas renin in the collecting ducts is dispensable for normal kidney development and cannot compensate for the lack of renin in the vascular compartment. Further, the main source of circulating renin is the kidney vasculature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.