Evidence map›Paper›PMID 26246487›Full record

ArticleOncotarget2015

A differentially expressed set of microRNAs in cerebro-spinal fluid (CSF) can diagnose CNS malignancies.

Alessandra Drusco, Arianna Bottoni, Alessandro Laganà, Mario Acunzo, Matteo Fassan, Luciano Cascione, Anna Antenucci, Prasanthi Kumchala, Caterina Vicentini, Marina P Gardiman and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. CSF Biopsy in Glioma: A Brief Review.Methods in molecular biology (Clifton, N.J.) · 2023
    Review
  18. Review
  19. Review
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Alessandra DruscoMVIMG, The Ohio State University, Columbus, OH, USA.
Arianna BottoniMVIMG, The Ohio State University, Columbus, OH, USA.
Alessandro LaganàDept. of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mario AcunzoMVIMG, The Ohio State University, Columbus, OH, USA.
Matteo FassanDept. of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, Padua, Italy.
Luciano CascioneLymphoma & Genomics Research Program, IOR Institute of Oncology Research, Bellinzona, Switzerland.
Anna AntenucciUOSD of Clinical Pathology, Regina Elena Institute, Rome, Italy.
Prasanthi KumchalaMVIMG, The Ohio State University, Columbus, OH, USA.
Caterina VicentiniARC-NET Research Centre, University and Hospital Trust of Verona, Verona, Italy.
Marina P GardimanDept. of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, Padua, Italy.
Hansjuerg AlderMVIMG, The Ohio State University, Columbus, OH, USA.
Mariantonia A CarosiDept. of Pathology, Regina Elena Institute, Rome, Italy.
Mario AmmiratiDept. of Neurological Surgery, The Ohio State University, OH, USA.
Stefano GherardiDept. of Anesthesiology, Sandro Pertini Hospital, Rome, Italy.
Marilena LuscrìDept. of Anesthesiology, Sandro Pertini Hospital, Rome, Italy.
Carmine CarapellaDept. of Neurological Surgery, Regina Elena Institute, Rome, Italy.
Nicola ZanesiMVIMG, The Ohio State University, Columbus, OH, USA.
Carlo M CroceMVIMG, The Ohio State University, Columbus, OH, USA.

Funding

MiRNAs/UCRs: biomarkers for cancer risk, tumor detection, progression & treatmentU01CA152758 · NCI · OHIO STATE UNIVERSITY · PI CROCE, CARLO M · 2010 to 2014
$1.8M
NCI NIH HHS U01 CA152758
6 · The paper itself

Abstract

Central Nervous System malignancies often require stereotactic biopsy or biopsy for differential diagnosis, and for tumor staging and grading. Furthermore, stereotactic biopsy can be non-diagnostic or underestimate grading. Hence, there is a compelling need of new diagnostic biomarkers to avoid such invasive procedures. Several biological markers have been proposed, but they can only identify specific prognostic subtype of Central Nervous System tumors, and none of them has found a standardized clinical application.The aim of the study was to identify a Cerebro-Spinal Fluid microRNA signature that could differentiate among Central Nervous System malignancies.CSF total RNA of 34 neoplastic and of 14 non-diseased patients was processed by NanoString. Comparison among groups (Normal, Benign, Glioblastoma, Medulloblastoma, Metastasis and Lymphoma) lead to the identification of a microRNA profile that was further confirmed by RT-PCR and in situ hybridization.Hsa-miR-451, -711, 935, -223 and -125b were significantly differentially expressed among the above mentioned groups, allowing us to draw an hypothetical diagnostic chart for Central Nervous System malignancies.This is the first study to employ the NanoString technique for Cerebro-Spinal Fluid microRNA profiling. In this article, we demonstrated that Cerebro-Spinal Fluid microRNA profiling mirrors Central Nervous System physiologic or pathologic conditions. Although more cases need to be tested, we identified a diagnostic Cerebro-Spinal Fluid microRNA signature with good perspectives for future diagnostic clinical applications.

Indexed as

BiomarkersBiomarkers, TumorBiopsyBrain NeoplasmsCentral Nervous System NeoplasmsCerebrospinal FluidDiagnosis, DifferentialGene Expression ProfilingGene Expression Regulation, NeoplasticGlioblastomaHumansIn Situ HybridizationMicroRNAsNanotechnologyNeoplasm StagingOligonucleotide Array Sequence AnalysisBiomarkersBiomarkers, TumorMicroRNAsbiomarkersbrain tumorscerebro-spinal fluid (CSF)microRNA

Identifiers

PMID26246487
PMCPMC4673232

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.