Evidence map›Paper›PMID 26246486›Full record

ArticleJournal of clinical microbiology2015

Lab-on-Chip-Based Platform for Fast Molecular Diagnosis of Multidrug-Resistant Tuberculosis.

Andrea M Cabibbe, Paolo Miotto, Raquel Moure, Fernando Alcaide, Silke Feuerriegel, Gianni Pozzi, Vladislav Nikolayevskyy, Francis Drobniewski, Stefan Niemann, Klaus Reither and 3 more

Registry-linked trialOpen access · bronzeAbstract readEvaluation Study
In one paragraph

Article in Journal of clinical microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03794284 (Performance of a Multiplex PCR -Microarray-based Assay in the Detection of Mycobacterium Tuberculosis and Non-tuberculous Mycobacterium Species in Smear-positive Pulmonary Clinical Specimens), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03794284 completednot on this mapstarted 2019, after this paper: background citation

Performance of a Multiplex PCR -Microarray-based Assay in the Detection of Mycobacterium Tuberculosis and Non-tuberculous Mycobacterium Species in Smear-positive Pulmonary Clinical Specimens

TypeobservationalSponsorChinese University of Hong KongRan2019 to 2022Enrolled46ConditionsTuberculosis, Non-Tuberculous Mycobacterial PneumoniaArmsVereMTB
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Microorganisms · 2020
    Review
  9. Article
  10. Article
  11. Article
  12. Experimental platform utilising melting curve technology for detection of mutations in Mycobacterium tuberculosis isolates.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018
    Article
  13. Microbiological Sensing Technologies: A Review.Bioengineering (Basel, Switzerland) · 2018
    Review
  14. Molecular Diagnosis of Tuberculosis.Chonnam medical journal · 2018
    Review
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 6 countries.

Andrea M CabibbeEmerging Bacterial Pathogens Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Paolo MiottoEmerging Bacterial Pathogens Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Raquel MoureServei de Microbiologia, Hospital Universitari de Bellvitge-IDIBELL, Universitat de Barcelona, Barcelona, Spain.
Fernando AlcaideServei de Microbiologia, Hospital Universitari de Bellvitge-IDIBELL, Universitat de Barcelona, Barcelona, Spain.
Silke FeuerriegelMolecular Mycobacteriology, Research Center Borstel, Borstel, Germany.
Gianni PozziLaboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Vladislav NikolayevskyyClinical TB and HIV Group, Blizard Institute, Queen Mary University of London, London, United Kingdom Department of Infectious Diseases and Immunity, Imperial College London, London, United Kingdom.
Francis DrobniewskiClinical TB and HIV Group, Blizard Institute, Queen Mary University of London, London, United Kingdom Department of Infectious Diseases and Immunity, Imperial College London, London, United Kingdom.
Stefan NiemannMolecular Mycobacteriology, Research Center Borstel, Borstel, Germany.
Klaus ReitherSwiss Tropical and Public Health Institute, Basel, Switzerland Ifakara Health Institute, Bagamoyo, United Republic of Tanzania.
Daniela M CirilloEmerging Bacterial Pathogens Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy cirillo.daniela@hsr.it.
TM-REST Consortium
TB-CHILD Consortium
Institut d'Investigació Biomédica de Bellvitge · ESQueen Mary University of London · GBResearch Center Borstel - Leibniz Lung Center · DEVita-Salute San Raffaele University · ITIstituto di Ricovero e Cura a Carattere Scientifico San RaffaeleSwiss Tropical and Public Health Institute · CHUniversity of Siena · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We evaluated the performance of the molecular lab-on-chip-based VerePLEX Biosystem for detection of multidrug-resistant tuberculosis (MDR-TB), obtaining a diagnostic accuracy of more than 97.8% compared to sequencing and MTBDRplus assay for Mycobacterium tuberculosis complex and rifampin and isoniazid resistance detection on clinical isolates and smear-positive specimens. The speed, user-friendly interface, and versatility make it suitable for routine laboratory use.

Indexed as

Lab-On-A-Chip DevicesAntitubercular AgentsDrug Resistance, Multiple, BacterialHumansIsoniazidMolecular Diagnostic TechniquesMycobacterium tuberculosisRifampinTuberculosis, Multidrug-ResistantAntitubercular AgentsIsoniazidRifampin

Identifiers

PMID26246486
PMCPMC4652106
OpenAlexW1959970300

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.