ArticleBiology letters2015
Naturally segregating loci exhibit epistasis for fitness.
Article in Biology letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Postzygotic barriers persist despite ongoing introgression in hybridizing Mimulus species.Molecular ecology · 2024Article
- The role of population and quantitative genetics and modern sequencing technologies to understand evolved herbicide resistance and weed fitness.Pest management science · 2021Article
- Predicting evolutionary change at the DNA level in a natural Mimulus population.PLoS genetics · 2021Article
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- Transgenerational effects alter plant defence and resistance in nature.Journal of evolutionary biology · 2017Article
- A Segregating Inversion Generates Fitness Variation in Yellow Monkeyflower (Mimulus guttatus).Genetics · 2016Article
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2 authors.
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Abstract
The extent to which gene interaction or epistasis contributes to fitness variation within populations remains poorly understood, despite its importance to a myriad of evolutionary questions. Here, we report a multi-year field study estimating fitness of Mimulus guttatus genetic lines in which pairs of naturally segregating loci exist in an otherwise uniform background. An allele at QTL x5b-a locus originally mapped for its effect on flower size-positively affects survival if combined with one genotype at quantitative trait locus x10a (aa) but has negative effects when combined with the other genotypes (Aa and AA). The viability differences between genotypes parallel phenotypic differences for the time and node at which a plant flowers. Viability is negatively correlated with fecundity across genotypes, indicating antagonistic pleiotropy for fitness components. This trade-off reduces the genetic variance for total fitness relative to the individual fitness components and thus may serve to maintain variation. Additionally, we find that the effects of each locus and their interaction often vary with the environment.
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