ArticlePsychopharmacology2015
Food restriction-induced augmentation of heroin seeking in female rats: manipulations of ovarian hormones.
Article in Psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Ovarian Hormones and Addictive Behaviour Vulnerability: Insights From Preclinical Studies.Addiction biology · 2025Pooled it
- Sex Differences in Opioid and Psychostimulant Craving and Relapse: A Critical Review.Pharmacological reviews · 2022Pooled it
- Sex-Specific Concordance of Striatal Transcriptional Signatures of Opioid Addiction in Human and Rodent Brains.Biological psychiatry global open science · 2025Article
- Sex-dependent effects of food-restriction on cocaine self-administration and cocaine-seeking in rats.Frontiers in behavioral neuroscience · 2025Article
- Estrogen receptor beta signaling enhances extinction memory recall for heroin-conditioned cues in a sex- and region-specific manner.Translational psychiatry · 2024Article
- The effects of gonadal hormones on heroin Self-Administration in male gonadectomized rats.Psychopharmacology · 2024Article
- Estradiol and Mu opioid-mediated reward: The role of estrogen receptors in opioid use.Addiction neuroscience · 2023Article
- The importance of translationally evaluating steroid hormone contributions to substance use.Frontiers in neuroendocrinology · 2023Review
- Modulation of morphine physical dependence and discriminative stimulus effects by ovarian hormones: Role of estradiol.Pharmacology, biochemistry, and behavior · 2022Article
- The effects of artificially induced proestrus on heroin intake: A critical role for estradiol.Experimental and clinical psychopharmacology · 2022Article
- Factors modulating the incubation of drug and non-drug craving and their clinical implications.Neuroscience and biobehavioral reviews · 2021Review
- Behavioral sex differences in cocaine and opioid use disorders: The role of gonadal hormones.Neuroscience and biobehavioral reviews · 2021Review
- The effects of chronic estradiol treatment on opioid self-administration in intact female rats.Drug and alcohol dependence · 2021Article
- The effects of strain and estrous cycle on heroin- and sugar-maintained responding in female rats.Behavioural brain research · 2021Article
- Modulation of heroin intake by ovarian hormones in gonadectomized and intact female rats.Psychopharmacology · 2021Article
- Assessing the Role of Corticothalamic and Thalamo-Accumbens Projections in the Augmentation of Heroin Seeking in Chronically Food-Restricted Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Cocaine and chronic stress exposure produce an additive increase in neuronal activity in the basolateral amygdala.Addiction biology · 2021Article
- Acute ovarian hormone treatment in freely cycling female rats regulates distinct aspects of heroin seeking.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Repeated restraint stress exposure during early withdrawal accelerates incubation of cue-induced cocaine craving.Addiction biology · 2018Article
- Modeling the development of drug addiction in male and female animals.Pharmacology, biochemistry, and behavior · 2018Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleFood restriction augments heroin seeking in chronically food-restricted male rats under withdrawal, an effect not yet examined in female rats. Importantly, women and female rats possess an increased vulnerability to drugs of abuse, which may be mediated by fluctuations in ovarian hormones.
objectivesWe investigated the role of estradiol and progesterone in augmented heroin seeking in chronically food-restricted female rats, under withdrawal.
methodsFemale rats self-administered heroin for 10-12 days and were then allowed unrestricted (sated) or restricted access to food (FDR; ∼10 % reduction in body weight) for 14 days. On day 14, rats underwent a heroin-seeking test. Exp. 1: Rats underwent ovariectomy or sham surgery and were treated with a low dose of estradiol (5.0 % in cholesterol; subcutaneous capsule). Exp. 2: Rats underwent ovariectomy and were administered with a high dose of estradiol (0.5 mg/kg; subcutaneous) for 8 days before testing. Exp. 3: Progesterone injections (2.0 mg/kg; subcutaneous) were administered 24 h and 2 h before testing.
resultsFood restriction resulted in augmented heroin seeking, compared to sated controls. While ovariectomy had no effect, estradiol replacement attenuated the food restriction effect. Injections of progesterone had no effect on heroin seeking in either the sated or FDR groups.
conclusionsThe effect of food restriction on heroin seeking in female rats under withdrawal is as robust as previously found in males. Interestingly, estradiol replacement, but not progesterone, attenuates the food restriction effect in the ovariectomized rats, possibly due to its anorexic properties.
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