Observational studyBMC infectious diseases2015
Reducing ventilator-associated pneumonia in neonatal intensive care unit using "VAP prevention Bundle": a cohort study.
Observational study in BMC infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07240038 (Evaluation of an Evidence Based, Bundled Intervention to Reduce Incidence of Ventilator-associated Pneumonia in Neonatal Units), which is not on this map. Cited by 31 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of an Evidence Based, Bundled Intervention to Reduce Incidence of Ventilator-associated Pneumonia in Neonatal Units (INBERNAV-Neo)
Who cites it
31 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Primary preventive interventions to reduce ventilator-associated pneumonia in neonatal intensive care units: a meta-analysis.Pediatric research · 2026Pooled it
- Prognosis of neonates receiving invasive mechanical ventilation in low-resource settings: a systematic review and prognostic meta-analysis.European journal of pediatrics · 2026Pooled it
- Prevention and Treatment of Neonatal Infections in Facility and Community Settings of Low- and Middle-Income Countries: A Descriptive Review.Neonatology · 2025Pooled it
- The Impact of Interventions to Prevent Neonatal Healthcare-associated Infections in Low- and Middle-income Countries: A Systematic Review.The Pediatric infectious disease journal · 2022Pooled it
- Factors Associated With Neonatal Pneumonia and its Mortality in India: A Systematic Review and Meta-Analysis.Indian pediatrics · 2021Pooled it
- Ventilator-associated pneumonia agents in Brazilian Neonatal Intensive Care Units - a systematic review.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesPooled it
- Review
- Customizing infection prevention and control modules for combating healthcare-acquired infections in low-resource hospitals or resource-constrained healthcare settings: a local and global approach.Antimicrobial resistance and infection control · 2026Article
- Ventilator-Associated Pneumonia in Newborns: Distribution of Causative Agents and Antibiogram.Sisli Etfal Hastanesi tip bulteni · 2026Article
- Ethical considerations regarding the treatment of extremely preterm infants at the limit of viability: a comprehensive review.European journal of pediatrics · 2025Review
- The spectrum of pneumonia among intubated neonates in the neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2024Review
- Early and consistent safe sleep practices in the neonatal intensive care unit: a sustained regional quality improvement initiative.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Ventilator-Associated Pneumonia in the Neonatal Intensive Care Unit-Incidence and Strategies for Prevention.Diagnostics (Basel, Switzerland) · 2024Review
- Effect of taurine supplementation on preventing ventilator-associated pneumonia in pediatrics under mechanical ventilation, a randomized controlled double-blind clinical trial.Frontiers in pediatrics · 2024Article
- The Status and Influencing Factors of COVID-19 Vaccination for 3-7-Year-Old Children Born Prematurely.Patient preference and adherence · 2024Article
- Review
- Endotracheal Aspirate and Ventilator-Associated Pneumonia in Neonates: Revisiting an Age-Old Debate.Indian journal of pediatrics · 2022Article
- Infection prevention and care bundles addressing health care-associated infections in neonatal care in low-middle income countries: a scoping review.EClinicalMedicine · 2022Article
- Healthcare-Associated Infection Prevention Interventions for Neonates in Resource-Limited Settings.Frontiers in pediatrics · 2022Review
- Practice Summary of Antimicrobial Therapy for Commonly Encountered Conditions in the Neonatal Intensive Care Unit: A Canadian Perspective.Frontiers in pediatrics · 2022Review
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVentilator-associated pneumonia (VAP) is a serious health care-associated infection, resulting in high morbidity and mortality. It also prolongs hospital stay and drives up hospital costs. Measures employed in preventing ventilator-associated pneumonia in developing countries are rarely reported. In this study we tried to assess the efficacy of our designed "VAP prevention bundle" in reducing VAP rate in our neonatal intensive care unit (NICU).
methodThis prospective before-and-after study was conducted at university hospital NICU, all neonates who had mechanical ventilation for ≥ 48 h were eligible. VAP rates were evaluated before (phase-I) and after (phase-II) full implementation of comprehensive preventive measures specifically designed by our infection control team.
resultsOf 143 mechanically ventilated neonates, 73 patients developed VAP (51%) throughout the study period (2500 mechanical ventilation days). The rate of VAP was significantly reduced from 67.8% (42/62) corresponding to 36.4 VAP episodes/1000 mechanical ventilation days (MV days) in phase-I to 38.2% (31/81) corresponding to 23 VAP/1000 MV days (RR 0.565, 95% confidence interval 0.408-0.782, p = 0.0006) after VAP prevention bundle implementation (phase-II). Parallel significant reduction in MV days/case were documented in post-intervention period (21.50 ± 7.6 days in phase-I versus 10.36 ± 5.2 days in phase-II, p = 0.000). There were a trend toward reduction in NICU length of stay (23.9 ± 10.3 versus 22.8 ± 9.6 days, p = 0.56) and overall mortality (25% versus 17.3%, p = 0.215) between the two phases but didn't reach statistical significance. The commonest micro-organisms isolated throughout the study were gram-negative bacteria (63/66, 95.5%) particularly Klebsilla pneumonia (55/66, 83.4%).
conclusionImplementation of multifaceted infection control bundle resulted in reduction of VAP rate, length of stay in our NICU.
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