Evidence map›Paper›PMID 26246100›Full record

ArticleThe neuroradiology journal2015

Perfusion computed tomography of intracranial meningiomas: In vivo correlation of cerebral blood volume and vascular permeability.

Francesca Granata, Rosa Morabito, Concetta Alafaci, Valeria Barresi, Francesco Tomasello, Sergio Vinci, Enricomaria Mormina, Alessandro Calamuneri, Giovanni Grasso, Francesco Maria Salpietro and 1 more

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Article in The neuroradiology journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

11 authors.

Francesca GranataDepartment of Biomedical Sciences and Morphological and Functional Images, University of Messina, Italy.
Rosa MorabitoDepartment of Biomedical Sciences and Morphological and Functional Images, University of Messina, Italy.
Concetta AlafaciDepartment of Neurosciences, University of Messina, Italy.
Valeria BarresiDepartment of Human Pathology, University of Messina, Italy.
Francesco TomaselloDepartment of Neurosciences, University of Messina, Italy.
Sergio VinciDepartment of Biomedical Sciences and Morphological and Functional Images, University of Messina, Italy.
Enricomaria MorminaDepartment of Biomedical Sciences and Morphological and Functional Images, University of Messina, Italy enricomaria.mormina@gmail.com.
Alessandro CalamuneriDepartment of Neurosciences, University of Messina, Italy.
Giovanni GrassoDepartment of Experimental Biomedicine and Clinical Neurosciences, University of Palermo, Italy.
Francesco Maria SalpietroDepartment of Neurosurgery, A.O. Ospedali Riuniti Papardo-Piemonte, University of Messina, Italy.
Marcello LongoDepartment of Biomedical Sciences and Morphological and Functional Images, University of Messina, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA noninvasive method to predict the grade of a meningioma would be desirable since it would anticipate information about tumour nature, recurrence and improve tumour management and outcomes. The aim of the present study was to assess the ability of perfusion computed tomography (PCT) technique in predicting the meningioma grade before surgery. Data from PCT, such as cerebral blood volume (CBV) and permeability surface (PS), were correlated with immunohistolopathological information.

methodsTwenty-three patients with a diagnosis of intracranial meningioma underwent PCT for pre-surgical evaluation of CBV and PS. During surgery, samples from the centre and periphery of the tumour were obtained. Two correspondent regions of interest (ROIs) were drawn on CBV and PS maps. Central and peripheral CBV and PS mean values were calculated. PCT parameters were correlated to CD-34 and endoglin.

resultsThere was a positive correlation between PS and CD-34. No correlation was found between PS values and endoglin, CBV values and CD-34 and endoglin values.

conclusionOur findings suggest that PCT may support conventional morphological imaging in predicting meningioma grading before surgery.

Indexed as

AgedBlood VolumeCapillary PermeabilityCerebrovascular CirculationCohort StudiesFemaleHumansMaleMeningeal NeoplasmsMeningiomaMiddle AgedNeoplasm GradingPerfusion ImagingProspective StudiesTomography, X-Ray ComputedCD-34endoglinMeningiomaneoangiogenesisperfusion computed tomographypermeability surface-area product

Identifiers

PMID26246100
PMCPMC4757289

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