ArticleSocial cognitive and affective neuroscience2016
Threat-related amygdala functional connectivity is associated with 5-HTTLPR genotype and neuroticism.
Article in Social cognitive and affective neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Task modulated brain connectivity of the amygdala: a meta-analysis of psychophysiological interactions.Brain structure & function · 2017Pooled it
- Functional brain responses to emotional faces after three to five weeks of intake of escitalopram in healthy individuals: a double-blind, placebo-controlled randomised study.Scientific reports · 2024Trial
- Neuroticism heterogeneity through item-level associations in resting-state functional connectivity.Communications biology · 2025Article
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- Gender Differences in Prefrontal Cortex Response to Negative Emotional Stimuli in Drivers.Brain sciences · 2024Article
- Neuroticism and openness exhibit an anti-correlation pattern to dissociable default mode network: using resting connectivity and structural equation modeling analysis.Brain imaging and behavior · 2024Article
- Genetic contributions to brain serotonin transporter levels in healthy adults.Scientific reports · 2023Article
- Circulating PACAP levels are associated with increased amygdala-default mode network resting-state connectivity in posttraumatic stress disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Association between brain serotonin 4 receptor binding and reactivity to emotional faces in depressed and healthy individuals.Translational psychiatry · 2023Article
- Article
- A neural model of vulnerability and resilience to stress-related disorders linked to differential susceptibility.Molecular psychiatry · 2022Review
- Understanding complex functional wiring patterns in major depressive disorder through brain functional connectome.Translational psychiatry · 2021Review
- Common HTR2A variants and 5-HTTLPR are not associated with human in vivo serotonin 2A receptor levels.Human brain mapping · 2020Article
- Insula serotonin 2A receptor binding and gene expression contribute to serotonin transporter polymorphism anxious phenotype in primates.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Neural correlates of social well-being: gray matter density in the orbitofrontal cortex predicts social well-being in emerging adulthood.Social cognitive and affective neuroscience · 2019Article
- Neuroticism predicts the impact of serotonin challenges on fear processing in subgenual anterior cingulate cortex.Scientific reports · 2018Article
- Functional connectivity of reflective and brooding rumination in depressed and healthy women.Cognitive, affective & behavioral neuroscience · 2018Article
- Predicting personality from network-based resting-state functional connectivity.Brain structure & function · 2018Article
- Association between Neuroticism and Emotional Face Processing.Scientific reports · 2017Article
- Violent offenders respond to provocations with high amygdala and striatal reactivity.Social cognitive and affective neuroscience · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Communication between the amygdala and other brain regions critically regulates sensitivity to threat, which has been associated with risk for mood and affective disorders. The extent to which these neural pathways are genetically determined or correlate with risk-related personality measures is not fully understood. Using functional magnetic resonance imaging, we evaluated independent and interactive effects of the 5-HTTLPR genotype and neuroticism on amygdala functional connectivity during an emotional faces paradigm in 76 healthy individuals. Functional connectivity between left amygdala and medial prefrontal cortex (mPFC) and between both amygdalae and a cluster including posterior cingulate cortex, precuneus and visual cortex was significantly increased in 5-HTTLPR S' allele carriers relative to L(A)L(A) individuals. Neuroticism was negatively correlated with functional connectivity between right amygdala and mPFC and visual cortex, and between both amygdalae and left lateral orbitofrontal (lOFC) and ventrolateral prefrontal cortex (vlPFC). Notably, 5-HTTLPR moderated the association between neuroticism and functional connectivity between both amygdalae and left lOFC/vlPFC, such that S' carriers exhibited a more negative association relative to L(A)L(A) individuals. These findings provide novel evidence for both independent and interactive effects of 5-HTTLPR genotype and neuroticism on amygdala communication, which may mediate effects on risk for mood and affective disorders.
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