ArticleWorld journal of urology2016
Risk of metastasis for T1a renal cell carcinoma.
Article in World journal of urology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 50 citations in OpenAlex.
- Active surveillance for renal masses up to 2 cm: long-term oncological outcomes from a prospective multi-institutional study.World journal of urology · 2026Trial
- Evaluation, Optimization, and Validation of a Multiparametric CT Algorithm for Solid Renal Masses: CT-Score Version 2.0.Radiology. Imaging cancer · 2026Article
- The added value of preoperative thoracic CT imaging in the management of T1a renal cell carcinoma.Acta radiologica (Stockholm, Sweden : 1987) · 2026Article
- Long-term oncological outcomes following percutaneous microwave ablation of T1 renal cell carcinoma.The British journal of radiology · 2025Article
- Metastatic Potential of Very Small (≤2 cm) Renal Cell Carcinoma: Insights from a Single-Center Experience and Review of the Literature.Journal of clinical medicine · 2025Article
- Imaging characteristics of renal epithelioid angiomyolipoma and its correlation with risk stratification.Scientific reports · 2025Article
- Prognostic outcomes of surgical modalities and predictive factors for distant metastases in T1a renal cell carcinoma: a SEER database analysis.Translational andrology and urology · 2025Article
- Development of modified multi-parametric CT algorithms for diagnosing clear-cell renal cell carcinoma in small solid renal masses.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025Article
- Clinical T1a Renal Cell Carcinoma with Solitary Diaphragmatic Metastasis in a Patient with von Hippel-Lindau Disease.Journal of kidney cancer and VHL · 2024Article
- Article
- Differentiation between renal epithelioid angiomyolipoma and clear cell renal cell carcinoma using clear cell likelihood score.Abdominal radiology (New York) · 2023Article
- Sarcomatoid Carcinoma Metastasis to the Colon from a Small Renal Mass: Case Report with Review of Literature.Journal of kidney cancer and VHL · 2023Article
- Predicting Oncologic Outcomes in Small Renal Tumors.European urology oncology · 2022Article
- Multicenter Evaluation of Multiparametric MRI Clear Cell Likelihood Scores in Solid Indeterminate Small Renal Masses.Radiology · 2022Article
- Clinical T1a Renal Cell Carcinoma, Not Always a Harmless Disease-A National Register Study.European urology open science · 2022Article
- Renal Oncocytoma: The Diagnostic Challenge to Unmask the Double of Renal Cancer.International journal of molecular sciences · 2022Review
- Predictive Factors Affecting Metastasis of Small Renal Mass and Its Prognostic Analysis.Clinical Medicine Insights. Oncology · 2022Article
- Usefulness of multidetector computed tomography to differentiate between renal cell carcinoma and oncocytoma. A model validation.The British journal of radiology · 2020Article
- Construction and Validation of a Convenient Clinical Nomogram to Predict the Risk of Brain Metastasis in Renal Cell Carcinoma Patients.BioMed research international · 2020Article
- Classification tree for the prediction of malignant disease and the prediction of non-diagnostic biopsies in patients with small renal masses.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2019Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionWhile active surveillance for small renal mass is gaining acceptance, controversy still continues on true metastatic potential of small renal cell carcinoma (RCC). Thus, we investigated the risks of synchronous/metachronous metastases and their potential predictors among T1a RCC patients who underwent surgical treatment.
methodsWe reviewed data from 2114 patients who received radical or partial nephrectomy for small renal tumor (≤ 4 cm) from 1990 to 2013. For our study, patients were stratified into four different groups according to tumor size (group 1: 0-1.0 cm, group 2: 1.1-2.0 cm, group 3: 2.1-3.0 cm, group 4: 3.1-4.0 cm). Univariate and multivariate analyses were performed to analyze metastatic potentials according to tumor size and identify useful predictors of metastases.
resultsAmong 1913 T1a RCC patients, there were low but nonnegligible rates of metastases (group 2: 1.1 %, group 3: 3.3 %, group 4: 6.0 %, respectively). Kaplan-Meier analysis showed significant differences in metastasis-free survivals between groups (p < 0.001). A linear positive association was observed between tumor size and metastatic rate (p < 0.001). Diabetic T1a RCC patients showed significantly inferior metastasis-free survival than nondiabetic counterparts (p = 0.003). Multivariate analysis revealed that tumor size and history of diabetes mellitus were independently associated with metastasis in T1a RCC.
conclusionsAs T1a RCCs present low but nonnegligible risk of metastasis, patients with small renal mass should be counseled on such risk when offered active surveillance. Larger tumor size and history of diabetes mellitus may be associated with higher risk of metastasis in T1a RCC.
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